Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Südufer 10, 17493 Greifswald-Insel Riems, Germany.
Vet Microbiol. 2010 Jul 14;143(2-4):189-95. doi: 10.1016/j.vetmic.2009.11.040. Epub 2009 Dec 4.
In late 2008, bluetongue virus (BTV) serotype 6 (BTV-6), which had never occurred in Europe before, was first detected in the Netherlands and Germany. While the origin of the virus remains unknown, the prevalence of infections in cattle was investigated in a virological (N=28,658) and serological (N=2075) field survey in Lower Saxony, where 45 cases confined to the district Grafschaft Bentheim were found. Blood from affected animals was used for the experimental infection of three cattle with different BTV antibody status, leading to sustained viraemia in one animal naïve for BTV. Of two animals that had detectable antibodies against BTV serotype 8, one became transiently infected and seroconverted for BTV-6 while the other did not react. In conclusion, while only a very limited spread of BTV-6 could be observed in the field, experimental infection of cattle did not show substantial differences of the course of infection in comparison to other BTV serotypes.
2008 年末，一种从未在欧洲出现过的乙型脑炎病毒 6 型（BTV-6）在荷兰和德国首次被发现。尽管该病毒的起源仍不清楚，但在下萨克森州进行了一项病毒学（N=28658）和血清学（N=2075）的实地调查，在那里发现了 45 例仅限于格拉夫施塔特县的病例。从受感染动物的血液中提取了三种具有不同乙型脑炎病毒抗体状态的牛进行实验感染，其中一只对乙型脑炎病毒无抗体的牛持续发生病毒血症。在两种对乙型脑炎病毒 8 型有检测到抗体的动物中，一只动物短暂感染并对 BTV-6 发生血清转化，而另一只动物则没有反应。总之，尽管在野外只能观察到 BTV-6 的非常有限的传播，但与其他乙型脑炎病毒血清型相比，牛的实验感染并没有显示出感染过程的实质性差异。
