College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea.
Bioorg Med Chem Lett. 2010 Feb 1;20(3):1000-3. doi: 10.1016/j.bmcl.2009.12.057. Epub 2009 Dec 21.
This study to investigate anti-influenza components from the bark of Alnus japonica resulted in the isolation of two rare acylated diarylheptanoids, named oregonoyl A (5) and oregonoyl B (6), along with nine known compounds (1-4 and 7-11). Their structures were elucidated on the basis of extensive spectroscopic and chemical methods. Antiviral testing of compounds 1-11 against KBNP-0028 (H9N2) avian influenza virus showed that platyphyllone (10) was strongly active, and platyphyllonol-5-xylopyranoside (9) was moderately active against KBNP-0028 as compared with the positive control, zanamivir, respectively.
本研究从桤木的树皮中提取到具有抗流感成分，分离得到了两种罕见的酰化二芳基庚烷类化合物，分别命名为奥里诺酰 A（5）和奥里诺酰 B（6），以及另外 9 种已知化合物（1-4 和 7-11）。它们的结构是基于广泛的光谱和化学方法确定的。对化合物 1-11 进行抗 KBNP-0028（H9N2）禽流感病毒活性测试表明，与阳性对照扎那米韦相比，扁柏酮（10）具有很强的活性，而扁柏酮-5-吡喃木糖苷（9）则具有中度活性。
