Department of Neurosurgery, Neurology, Oncological Sciences, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1136, New York, NY 10029, USA.
Neuropharmacology. 2010 May;58(6):903-10. doi: 10.1016/j.neuropharm.2009.12.019. Epub 2010 Jan 1.
The discovery of brain tumor-derived cells (BTSC) with the properties of stem cells has led to the formulation of the hypothesis that neural stem cells could be the cell of origin of primary brain tumors (PBT). In this review we present the most common molecular changes in PBT, define the criteria of identification of BTSC and discuss the similarities between the characteristics of these cells and those of the endogenous population of neural stem cells (NPCs) residing in germinal areas of the adult brain. Finally, we propose possible mechanisms of cancer initiation and progression and suggest a model of tumor initiation that includes intrinsic changes of resident NSC and potential changes in the microenvironment defining the niche where the NSC reside.
脑肿瘤衍生细胞(BTSC)具有干细胞特性的发现,导致了这样一种假说的提出,即神经干细胞可能是原发性脑肿瘤(PBT)的起源细胞。在这篇综述中,我们介绍了 PBT 中最常见的分子变化,定义了 BTSC 的鉴定标准,并讨论了这些细胞的特征与存在于成年大脑生殖区域的内源性神经干细胞(NPCs)之间的相似性。最后,我们提出了癌症起始和进展的可能机制,并提出了一个肿瘤起始模型,该模型包括驻留 NSC 的内在变化和定义 NSC 所在小生境的微环境的潜在变化。