Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Brain Tumor Pathol. 2013 Oct;30(4):209-14. doi: 10.1007/s10014-013-0141-5. Epub 2013 Apr 13.
The cancer stem cell theory postulates that tumors are sustained by a select cell population with specific features, such as self-renewal ability and the capacity to give rise to a heterogeneous mass of tumor cells. The existence of such cells has been demonstrated for glioblastoma, with these cells being referred to as glioma stem cells (GSCs). Glioblastomas are notoriously heterogeneous tumors, however, and the isolation and characterization of their stem cells will require further investigations. Furthermore, the lack of unequivocal markers for GSCs and a partial overlap in characteristics with other cells often lead to confusion. Here, we review the characteristics necessary for a glioma cell to be considered a stem cell, and we adopt our murine glioblastoma model based on genetically modified neural stem cells to illustrate and discuss the GSC concept.
癌症干细胞理论假设肿瘤是由具有特定特征的特定细胞群维持的，例如自我更新能力和产生异质性肿瘤细胞群的能力。已经证明了这些细胞在胶质母细胞瘤中存在，这些细胞被称为神经胶质瘤干细胞（GSCs）。然而，胶质母细胞瘤是出了名的异质性肿瘤，因此需要进一步研究来分离和表征它们的干细胞。此外，由于缺乏明确的 GSC 标志物以及与其他细胞的特征部分重叠，常常导致混淆。在这里，我们回顾了将神经胶质瘤细胞视为干细胞所需的特征，并采用基于基因修饰神经干细胞的我们的小鼠胶质母细胞瘤模型来阐明和讨论 GSC 概念。
