Department of Pharmaceutical Chemistry, Ultra College of Pharmacy, Madurai 625 020, Tamil Nadu, India.
J Ethnopharmacol. 2010 Mar 2;128(1):248-50. doi: 10.1016/j.jep.2009.12.030. Epub 2010 Jan 4.
Traditionally the aqueous extracts of dried roots of the plant Ecbolium viride are used for menorrhagia, rheumatism and jaundice.
The aim was to evaluate the anti-inflammatory activity of Ecbolium viride extract in an in vivo model.
The ethyl acetate fraction of Ecbolium viride root extract was prepared and administered orally to rats. The anti-inflammatory activity of Ecbolium viride was determined by carrageenan-induced paw edema and cotton pellet granuloma models.
Oral administration of Ecbolium viride extract reduced inflammation significantly (P<0.01) in both the carageenan paw edema and the cotton pellet granuloma models.
The results of the study supported the traditional use of Ecbolium viride in the treatment for inflammatory disease.
传统上，该植物绿升麻的干燥根的水提物被用于月经过多、风湿和黄疸。
本研究旨在评估绿升麻提取物在体内模型中的抗炎活性。
制备绿升麻根提取物的乙酸乙酯部分，并对大鼠进行口服给药。通过角叉菜胶诱导的足肿胀和棉塞肉芽肿模型来确定绿升麻的抗炎活性。
绿升麻提取物的口服给药在角叉菜胶诱导的足肿胀和棉塞肉芽肿模型中均显著减轻炎症（P<0.01）。
该研究结果支持绿升麻传统上用于治疗炎症性疾病。
