Schulich Faculty of Chemistry, Technion - Israel Institute of Technology, Haifa 32000, Israel.
J Magn Reson. 2010 Mar;203(1):150-5. doi: 10.1016/j.jmr.2009.12.011. Epub 2009 Dec 22.
Microcrystals of lithium octa-n-butoxynaphthalocyanine (LiNc-BuO) in a bio-compatible and oxygen-permeable polymer matrix of poly-dimethyl-siloxane (PDMS) can be used for repetitive non-invasive imaging of oxygen in live specimens by means of mm-scale electron spin resonance (ESR) imaging. This probe denoted as "oxychip" was characterized by high-resolution mum-scale ESR microcopy to reveal the fine details of its spatial and spectral properties. The ESR micro-images of a typical oxychip device showed that while the spatial distribution of the microcrystals in the polymer is fairly homogenous (as revealed by optical microscopy), the ESR signal originates only from a very few dominant crystals. Furthermore, spectral-spatial analysis in a microcrystal and a sub-microcrystal spatial resolution reveals that each crystal has a slightly different g-factor and also exhibits variations in linewidth, possibly due to the slightly different individual crystallization process.
八正丁氧基酞菁化锂（LiNc-BuO）的微晶可以在生物相容性和透气的聚二甲基硅氧烷（PDMS）聚合物基质中使用，通过毫米级的电子自旋共振（ESR）成像来对活体标本中的氧进行重复的非侵入式成像。这种被称为“氧芯片”的探针通过高分辨率的毫微米级 ESR 显微镜来揭示其空间和光谱特性的细节。典型的氧芯片装置的 ESR 微图像表明，虽然聚合物中的微晶体的空间分布相当均匀（通过光学显微镜揭示），但 ESR 信号仅来自极少数主导晶体。此外，在微晶体和亚微晶体空间分辨率下的光谱-空间分析表明，每个晶体的 g 因子略有不同，并且还表现出线宽的变化，这可能是由于略有不同的单个结晶过程。
