Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
Road Traffic Injury Research Center, Tabriz Health Services Management Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
BMC Endocr Disord. 2024 Jun 24;24(1):95. doi: 10.1186/s12902-024-01621-5.
Metabolic syndrome (MetS) is a cluster of risk factors and the Framingham risk score (FRS) is a useful metric for measuring the 10-year cardiovascular disease (CVD) risk of the population. The present study aimed to determine the 10-year risk of cardiovascular disease using the Framingham risk score in people with and without MetS in a large Iranian cohort study.
This cross-sectional study was done using the Fasa cohort. Participants aged ≥ 35 years old were recruited to the study from 2015 to 2016. The FRS was calculated using age, sex, current smoking, diabetes, systolic blood pressure (SBP), total cholesterol, and high-density lipoprotein (HDL) cholesterol. MetS was defined as the presence of three or more of the MetS risk factors including triglyceride (TG) level ≥ 150 mg dl, HDL level < 40 mg dl in men and < 50 mg dl in women, systolic/diastolic blood pressure ≥ 130/≥85 mmHg or using medicine for hypertension, fasting blood sugar (FBS) level ≥ 100 mg dl or using diabetes medication and abdominal obesity considered as waist circumference (WC) ≥ 88 cm for women and ≥ 102 cm for men. Multiple logistic regressions were applied to estimate the 10- year CVD risk among people with and without MetS.
Of 8949 participants, 1928 people (21.6%) had MetS. The mean age of the participants with and without Mets was 50.4 ± 9.2 years and 46.9 ± 9.1 years respectively. In total 15.3% of participants with MetS and 8.0% of participants without MetS were in the high-risk category of 10-year CVD risk. Among participants with MetS gender, TG, SBP, FBS and in people without MetS gender, TG, SBP, FBS, and HDL showed strong associations with the predicted 10-year CVD risk.
Male sex and increased SBP, TG, and FBS parameters were strongly associated with increased 10-year risk of CVD in people with and without MetS. In people without MetS, reduced HDL-cholestrol was strongly associated with increased 10-year risk of CVD. The recognition of participant's TG, blood pressure (BP), FBS and planning appropriate lifestyle interventions related to these characteristics is an important step towards prevention of CVD.
代谢综合征（MetS）是一组风险因素，弗雷明汉风险评分（FRS）是衡量人群 10 年心血管疾病（CVD）风险的有用指标。本研究旨在通过大型伊朗队列研究，确定患有和不患有代谢综合征人群的Framingham 风险评分的 10 年 CVD 风险。
本横断面研究使用 Fasa 队列进行。2015 年至 2016 年期间，招募了年龄≥35 岁的参与者参加该研究。使用年龄、性别、当前吸烟状况、糖尿病、收缩压（SBP）、总胆固醇和高密度脂蛋白（HDL）胆固醇计算 FRS。代谢综合征定义为存在三种或三种以上代谢综合征危险因素，包括甘油三酯（TG）水平≥150mg/dl，男性 HDL 水平<40mg/dl，女性<50mg/dl，收缩压/舒张压≥130/≥85mmHg 或使用降压药物，空腹血糖（FBS）水平≥100mg/dl 或使用糖尿病药物和腹部肥胖，女性腰围≥88cm，男性腰围≥102cm。应用多变量逻辑回归估计患有和不患有代谢综合征人群的 10 年 CVD 风险。
在 8949 名参与者中，有 1928 人（21.6%）患有代谢综合征。患有和不患有 Mets 的参与者的平均年龄分别为 50.4±9.2 岁和 46.9±9.1 岁。患有代谢综合征的参与者中，有 15.3%处于 10 年 CVD 风险的高危类别，而不患有代谢综合征的参与者中，有 8.0%处于该类别。在患有代谢综合征的人群中，性别、TG、SBP、FBS，以及在不患有代谢综合征的人群中，性别、TG、SBP、FBS 和 HDL 与预测的 10 年 CVD 风险呈强关联。
男性和增加的 SBP、TG 和 FBS 参数与患有和不患有代谢综合征人群的 10 年 CVD 风险增加密切相关。在不患有代谢综合征的人群中，HDL-胆固醇的降低与 10 年 CVD 风险的增加密切相关。认识到参与者的 TG、血压（BP）、FBS 并计划与之相关的适当生活方式干预措施是预防 CVD 的重要步骤。
