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治疗:狼疮中的羟氯喹:老药,新视角。

Therapy: Hydroxychloroquine in SLE: old drug, new perspectives.

出版信息

Nat Rev Rheumatol. 2010 Jan;6(1):10-1. doi: 10.1038/nrrheum.2009.235.

DOI:10.1038/nrrheum.2009.235
PMID:20046202
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7097534/
Abstract

Antimalarial agents have long been used in the treatment of autoimmune diseases, despite uncertainty regarding the exact mechanisms underlying their various effects. Growing evidence that these drugs offer protection from major infections could stimulate more research into these mechanisms, with possible implications for therapy.

摘要

抗疟药物长期以来一直被用于治疗自身免疫性疾病,尽管其各种作用的确切机制尚不确定。越来越多的证据表明,这些药物可以预防重大感染,这可能会促使人们更多地研究这些机制,并可能对治疗产生影响。

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本文引用的文献

1
Protective effect of hydroxychloroquine on renal damage in patients with lupus nephritis: LXV, data from a multiethnic US cohort.羟氯喹对狼疮性肾炎患者肾损伤的保护作用:LXV,来自美国多民族队列的数据。
Arthritis Rheum. 2009 Jun 15;61(6):830-9. doi: 10.1002/art.24538.
2
Risk and protective factors for thrombosis in systemic lupus erythematosus: results from a large, multi-ethnic cohort.系统性红斑狼疮血栓形成的风险和保护因素:来自一个大型多民族队列的结果。
Ann Rheum Dis. 2009 Feb;68(2):238-41. doi: 10.1136/ard.2008.093013. Epub 2008 Sep 9.
3
Previous antimalarial therapy in patients diagnosed with lupus nephritis: influence on outcomes and survival.狼疮性肾炎患者既往的抗疟治疗:对治疗结果和生存率的影响。
Lupus. 2008 Apr;17(4):281-8. doi: 10.1177/0961203307086503.
4
Vitamin D deficiency in systemic lupus erythematosus: prevalence, predictors and clinical consequences.系统性红斑狼疮中的维生素D缺乏:患病率、预测因素及临床后果
Rheumatology (Oxford). 2008 Jun;47(6):920-3. doi: 10.1093/rheumatology/ken121. Epub 2008 Apr 14.
5
The risk of hospitalized infection in patients with rheumatoid arthritis.类风湿关节炎患者发生医院感染的风险。
J Rheumatol. 2008 Mar;35(3):387-93. Epub 2008 Feb 1.
6
Hydroxychloroquine sulfate treatment is associated with later onset of systemic lupus erythematosus.硫酸羟氯喹治疗与系统性红斑狼疮的发病延迟有关。
Lupus. 2007;16(6):401-9. doi: 10.1177/0961203307078579.
7
Recycling of chloroquine and its hydroxyl analogue to face bacterial, fungal and viral infections in the 21st century.氯喹及其羟基类似物的再利用以应对21世纪的细菌、真菌和病毒感染。
Int J Antimicrob Agents. 2007 Oct;30(4):297-308. doi: 10.1016/j.ijantimicag.2007.05.015. Epub 2007 Jul 16.
8
Deficiency of functional mannose-binding lectin is not associated with infections in patients with systemic lupus erythematosus.功能性甘露糖结合凝集素缺乏与系统性红斑狼疮患者的感染无关。
Arthritis Res Ther. 2006;8(6):R183. doi: 10.1186/ar2095.
9
Effect of antimalarials on thrombosis and survival in patients with systemic lupus erythematosus.抗疟药对系统性红斑狼疮患者血栓形成及生存的影响。
Lupus. 2006;15(9):577-83. doi: 10.1177/0961203306071872.
10
A long-term study of hydroxychloroquine withdrawal on exacerbations in systemic lupus erythematosus. The Canadian Hydroxychloroquine Study Group.一项关于停用羟氯喹对系统性红斑狼疮病情加重影响的长期研究。加拿大羟氯喹研究小组。
Lupus. 1998;7(2):80-5. doi: 10.1191/096120398678919778.