Nat Rev Rheumatol. 2010 Jan;6(1):10-1. doi: 10.1038/nrrheum.2009.235.
Antimalarial agents have long been used in the treatment of autoimmune diseases, despite uncertainty regarding the exact mechanisms underlying their various effects. Growing evidence that these drugs offer protection from major infections could stimulate more research into these mechanisms, with possible implications for therapy.
抗疟药物长期以来一直被用于治疗自身免疫性疾病,尽管其各种作用的确切机制尚不确定。越来越多的证据表明,这些药物可以预防重大感染,这可能会促使人们更多地研究这些机制,并可能对治疗产生影响。