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决明子不同提取物对四氧嘧啶糖尿病大鼠的降血糖活性

Antihyperglycemic Activity of Various Fractions of Cassia auriculata Linn. in Alloxan Diabetic Rats.

作者信息

Surana S J, Gokhale S B, Jadhav R B, Sawant R L, Wadekar Jyoti B

机构信息

P. D. V. V. P. F's College of Pharmacy, Vilad Ghat, Post MIDC, Ahmednagar-414 111, India.

出版信息

Indian J Pharm Sci. 2008 Mar-Apr;70(2):227-9. doi: 10.4103/0250-474X.41461.

DOI:10.4103/0250-474X.41461
PMID:20046718
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2792492/
Abstract

Present work describes the potent antidiabetic fraction from flowers of Cassia auriculata Linn. Hydromethanolic extract along with its ethyl acetate and n-butanol fractions were evaluated for antidiabetic activity in alloxan-induced diabetes in rats. The n-butanol fraction exhibited significant reduction (p<0.001) in blood glucose levels and was also found effective in restoring the blood lipids and proteins to normal level. The activity was found comparable with standard drug phenformin. The hydromethanolic extract and its fractions were subjected to preliminary qualitative chemical investigations which indicated the presence of phenolic compounds, carbohydrates, tannins, steroids and amino acids.

摘要

目前的研究描述了决明花的有效抗糖尿病成分。对甲醇提取物及其乙酸乙酯和正丁醇馏分在大鼠四氧嘧啶诱导的糖尿病模型中进行抗糖尿病活性评估。正丁醇馏分使血糖水平显著降低（p<0.001），并且还能有效将血脂和蛋白质恢复到正常水平。该活性与标准药物苯乙双胍相当。对甲醇提取物及其馏分进行了初步的定性化学研究，结果表明存在酚类化合物、碳水化合物、单宁、类固醇和氨基酸。