无花果叶提取物对利福平诱导的大鼠肝损伤的保肝活性
Hepatoprotective Activity of Ficus carica Leaf Extract on Rifampicin-Induced Hepatic Damage in Rats.
作者信息
Gond N Y, Khadabadi S S
机构信息
Department of Pharmacognosy, Nanded Pharmacy College, Nanded-431 605, India.
出版信息
Indian J Pharm Sci. 2008 May-Jun;70(3):364-6. doi: 10.4103/0250-474X.43003.
Abstract
Shade dried leaves of Ficus carica were extracted using petroleum ether (60-80 degrees ) and tested for antihepatotoxic activity on rats treated with 50 mg/kg of rifampicin orally. The parameters assessed were serum levels of glutamic oxaloacetate transaminase, glutamic pyruvic transaminase, bilirubin and histological changes in liver. Liver weights and pentobarbitione sleeping time as a functional parameter were also monitored. There was significant reversal of biochemical, histological and functional changes induced by rifampicin treatment in rats by petroleum ether extract treatment, indicating promising hepatoprotective activity.
摘要
将无花果的阴干叶用石油醚（60 - 80度）提取，并对口服50 mg/kg利福平处理的大鼠进行抗肝毒性活性测试。评估的参数包括血清谷氨酸草酰乙酸转氨酶、谷氨酸丙酮酸转氨酶、胆红素水平以及肝脏的组织学变化。还监测了肝脏重量和作为功能参数的戊巴比妥睡眠时间。石油醚提取物处理可显著逆转利福平处理诱导的大鼠生化、组织学和功能变化，表明其具有良好的肝保护活性。
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