验证的HPTLC法同时测定片剂剂型中盐酸喹那普利和氢氯噻嗪的含量
Validated HPTLC Method for Simultaneous Determination of Quinapril Hydrochloride and Hydrochlorothiazide in a Tablet Dosage Form.
作者信息
Bhavar Girija B, Chatpalliwar V A, Patil D D, Surana S J
机构信息
Department of Pharmaceutical Chemistry, R. C. Patel College of Pharmacy Karvand Naka, Shirpur, Dist: Dhule-425 405, India.
出版信息
Indian J Pharm Sci. 2008 Jul-Aug;70(4):529-31. doi: 10.4103/0250-474X.44612.
Abstract
Quinapril hydrochloride and hydrochlorothiazide were simultaneously determined by HPTLC in pharmaceutical formulations. The drugs were separated on silica gel 60 F(254) plates using suitable combination of solvents as mobile phase. The validation parameters, tested in accordance with the requirements of ICH guidelines, prove the suitability of methods.
摘要
采用高效薄层色谱法（HPTLC）同时测定药物制剂中的盐酸喹那普利和氢氯噻嗪。以硅胶60 F(254)板为固定相，选用合适的溶剂组合作为流动相分离药物。按照国际人用药品注册技术协调会（ICH）指南的要求进行验证参数测试，结果证明该方法适用。
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