Tsutsui Hideaki, Ho Chih-Ming
Mechanical and Aerospace Engineering Department, University of California, Los Angeles, Los Angeles, CA 90095, United States.
Mech Res Commun. 2009 Jan 1;36(1):92-103. doi: 10.1016/j.mechrescom.2008.08.006.
Cell and microparticle separation in microfluidic systems has recently gained significant attention in sample preparations for biological and chemical studies. Microfluidic separation is typically achieved by applying differential forces on the target particles to guide them into different paths. This paper reviews basic concepts and novel designs of such microfluidic separators with emphasis on the use of non-inertial force fields, including dielectrophoretic force, optical gradient force, magnetic force, and acoustic primary radiation force. Comparisons of separation performances with discussions on physiological effects and instrumentation issues toward point-of-care devices are provided as references for choosing appropriate separation methods for various applications.
微流控系统中的细胞和微粒分离最近在生物和化学研究的样品制备中受到了广泛关注。微流控分离通常是通过对目标颗粒施加不同的力，引导它们进入不同的路径来实现的。本文综述了此类微流控分离器的基本概念和新颖设计，重点介绍了非惯性力场的应用，包括介电泳力、光梯度力、磁力和声初级辐射力。文中还提供了分离性能的比较，并讨论了对即时检测设备的生理影响和仪器问题，为各种应用选择合适的分离方法提供参考。
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