Gandra Naveen, Chiu Pui Lam, Li Wenbing, Anderson Yolanda R, Mitra Somenath, He Huixin, Gao Ruomei
Department of Chemistry, Jackson State University, Jackson, Mississippi 39211.
J Phys Chem C Nanomater Interfaces. 2009;113(13):5182-8185. doi: 10.1021/jp809268q.
Single-walled carbon nanotubes (SWNTs) functionalized with -COOH (along with some sulphonation and nitration), and/or modified with chitosan were prepared and tested for their singlet oxygen ((1)O(2)) production. The emission from (1)O(2) observed upon SWNT irradiation at 532 nm was due to a two-photon process, while (1)O(2) production via excitation at 355 nm occurred through a conventional one-photon pathway. The relative quantum yield of (1)O(2) production at excitation wavelength of 532 nm was found to be 0.00, 0.07-0.13 and 0.24-0.54 for highly-functionalized, partially-functionalized and non-functionalized SWNT samples respectively. The nanotube-mediated generation of (1)O(2) may find applications in both targeted destruction of tumor cells and selective degradation of drug molecules. Our research provides a practical approach to modulate the production of reactive oxygen species from SWNTs via surface functionalization/modification.
制备了用-COOH官能化（伴有一些磺化和硝化）和/或用壳聚糖改性的单壁碳纳米管（SWNTs），并测试了它们产生单线态氧（(1)O(2)）的能力。在532nm处对SWNTs进行辐照时观察到的(1)O(2)发射是由于双光子过程，而在355nm处激发产生(1)O(2)则是通过传统的单光子途径。发现在532nm激发波长下，高度官能化、部分官能化和未官能化的SWNT样品产生(1)O(2)的相对量子产率分别为0.00、0.07 - 0.13和0.24 - 0.54。纳米管介导的(1)O(2)生成可能在肿瘤细胞的靶向破坏和药物分子的选择性降解中都有应用。我们的研究提供了一种通过表面官能化/改性来调节SWNTs产生活性氧的实用方法。
