Ren Anjing, Qin Tingting, Wang Qianqian, Du Haina, Zhong Donghua, Hua Yibing, Zhu Lingjun
Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Department of Oncology, The Third Affiliated Hospital of Nanjing University of T.C.M, Nanjing, China.
J Cell Mol Med. 2016 Sep;20(9):1620-31. doi: 10.1111/jcmm.12853. Epub 2016 Apr 6.
Cytochrome P450 1A1 (CYP1A1) is a phase I enzyme that regulates the metabolism of environmental carcinogens and alter the susceptibility to various cancers. Many studies have investigated the association between the CYP1A1 MspI and Ile462Val polymorphisms and digestive tract cancer (DTC) risk in different groups of populations, but their results were inconsistent. The PubMed and Embase Database were searched for case-control studies published up to 30th September, 2015. Data were extracted and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the relationship. Totally, 39 case-control studies (9094 cases and 12,487 controls) were included. The G allele in Ile/Val polymorphism was significantly associated with elevated DTC risk with per-allele OR of 1.24 (95% CI = 1.09-1.41, P = 0.001). Similar results were also detected under the other genetic models. Evidence was only found to support an association between MspI polymorphism and DTC in the subgroups of caucasian and mixed individuals, but not in the whole population (the dominant model: OR = 1.19, 95% CI = 0.94-1.91, P = 0.146). In conclusion, our results suggest that the CYP1A1 polymorphisms are potential risk factors for DTC. And large sample size and well-designed studies with detailed clinical information are needed to more precisely evaluate our founding.
细胞色素P450 1A1（CYP1A1）是一种I相酶，可调节环境致癌物的代谢并改变对各种癌症的易感性。许多研究调查了CYP1A1 MspI和Ile462Val多态性与不同人群组中消化道癌（DTC）风险之间的关联，但其结果并不一致。检索了PubMed和Embase数据库中截至2015年9月30日发表的病例对照研究。提取数据并计算合并比值比（OR）及其95%置信区间（CI）以评估两者之间的关系。总共纳入了39项病例对照研究（9094例病例和12487例对照）。Ile/Val多态性中的G等位基因与DTC风险升高显著相关，每个等位基因的OR为1.24（95%CI = 1.09 - 1.41，P = 0.001）。在其他遗传模型下也检测到了类似结果。仅在白种人和混血个体亚组中发现证据支持MspI多态性与DTC之间的关联，而在整个人口中未发现（显性模型：OR = 1.19，95%CI = 0.94 - 1.91，P = 0.146）。总之，我们的结果表明CYP1A1多态性是DTC的潜在危险因素。需要大样本量且设计良好并带有详细临床信息的研究来更精确地评估我们的发现。
