Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.
BMC Cancer. 2010 Jan 4;10:1. doi: 10.1186/1471-2407-10-1.
A common treatment option for men with prostate cancer is androgen deprivation therapy (ADT). However, men undergoing ADT may experience physical side effects, changes in quality of life and sometimes psychiatric and cognitive side effects.
In this study, hormone naïve patients without evidence of metastases with a rising PSA were treated with nine months of ADT. Functional magnetic resonance imaging (fMRI) of the brain during three visuospatial tasks was performed at baseline prior to treatment and after nine months of ADT in five subjects. Seven healthy control patients, underwent neuroimaging at the same time intervals.
ADT patients showed reduced, task-related BOLD-fMRI activation during treatment that was not observed in control subjects. Reduction in activation in right parietal-occipital regions from baseline was observed during recall of the spatial location of objects and mental rotation.
Findings, while preliminary, suggest that ADT reduces task-related neural activation in brain regions that are involved in mental rotation and accurate recall of spatial information.
雄激素剥夺疗法（ADT）是治疗前列腺癌患者的常用方法。然而，接受 ADT 的男性可能会出现身体副作用、生活质量改变，有时还会出现精神和认知副作用。
在这项研究中，对没有转移证据且 PSA 升高的激素初治患者进行了 9 个月的 ADT。在治疗前和 9 个月 ADT 后，对 5 名患者进行了三次视觉空间任务的脑功能磁共振成像（fMRI）。同时，7 名健康对照患者在相同的时间间隔进行了神经影像学检查。
ADT 患者在治疗期间表现出与任务相关的大脑 BOLD-fMRI 激活减少，而对照组患者则没有观察到这种现象。在回忆物体的空间位置和心理旋转时，右侧顶枕叶区域的激活从基线开始减少。
虽然这些发现尚属初步，但提示 ADT 可减少与精神旋转和准确回忆空间信息相关的大脑区域的任务相关神经激活。
