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颅内硬脑膜窦血栓形成:机械取栓导管的新应用及治疗策略综述

Intracranial dural sinus thrombosis: novel use of a mechanical thrombectomy catheter and review of management strategies.

作者信息

Khan Shah-Naz Hayat, Adeoye Opeolu, Abruzzo Todd Anthony, Shutter Lori A, Ringer Andrew Joel

机构信息

The Neuroscience Institute,University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

出版信息

Clin Med Res. 2009 Dec;7(4):157-65. doi: 10.3121/cmr.2009.847.

Abstract

Management of intracranial dural sinus thrombosis with involvement of multiple sinuses is complex, often involving not only the primary problem (thrombosis) but acute adverse events consequent to the disease. We highlight the novel use of an endovascular device (typically for suction thrombectomy in the peripheral vascular system) used in our patient with a life-threatening multi-sinus thrombosis. As there is no standard treatment yet for cranial sinus thrombosis, our review of the literature highlights some effective management strategies. A 35-year-old woman developed associated complications of cranial sinus thrombosis that included intracranial hypertension caused by an expanding intracranial hematoma, pulmonary embolism treated by placement of filters in superior and inferior vena cava to eliminate intra- and extracranial sources of emboli, and procedure-related retroperitoneal hematoma that necessitated peripheral vascular intervention. After failure of several common devices during mechanical thrombolysis, a thrombectomy catheter (typically for peripheral vascular intervention to aide in the clot removal) was used. Our case highlights the fine balance of anticoagulation and thrombolysis and the proactive, aggressive approach used by our multispecialty team to manage concurrent factors.

摘要

多窦受累的颅内硬脑膜窦血栓形成的管理很复杂,不仅常常涉及主要问题(血栓形成),还涉及该疾病引发的急性不良事件。我们着重介绍了一种血管内装置(通常用于外周血管系统的抽吸血栓切除术)在我们一位患有危及生命的多窦血栓形成患者中的新应用。由于目前尚无针对颅窦血栓形成的标准治疗方法,我们对文献的回顾突出了一些有效的管理策略。一名35岁女性出现了颅窦血栓形成的相关并发症,包括因颅内血肿扩大导致的颅内高压、通过在上腔静脉和下腔静脉放置滤器以消除颅内和颅外栓子来源来治疗的肺栓塞,以及需要进行外周血管干预的与手术相关的腹膜后血肿。在机械溶栓过程中几种常用装置失效后,使用了一种血栓切除术导管(通常用于外周血管干预以辅助清除血栓)。我们的病例突出了抗凝和溶栓之间的微妙平衡,以及我们的多专业团队为处理并发因素所采用的积极、激进的方法。

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