Risberg B, Medegård A, Heideman M, Gyzander E, Bundsen P, Odén M, Teger-Nilsson A C
Crit Care Med. 1986 Nov;14(11):917-25. doi: 10.1097/00003246-198611000-00001.
Coagulation, fibrinolytic, kallikrein, and complement systems were studied in 20 patients with multiple trauma. Three of four patients with a trauma score less than 10 on hospital arrival died, compared to one of 16 with a score over 10. Five patients developed disseminated intravascular coagulation. Signs of activated cascade systems were evident in most patients on hospital arrival. Changes were not related to trauma score, but patients with an arterial pressure below 110 mm Hg had significantly lower levels of antithrombin III and alpha 2-antiplasmin than those with higher BP. This study confirms that the cascade systems are activated very soon after multiple trauma.
对20例多发伤患者的凝血、纤溶、激肽释放酶和补体系统进行了研究。入院时创伤评分低于10分的4例患者中有3例死亡，而评分高于10分的16例患者中有1例死亡。5例患者发生了弥散性血管内凝血。大多数患者入院时激活的级联系统迹象明显。这些变化与创伤评分无关，但动脉压低于110 mmHg的患者抗凝血酶III和α2 -抗纤溶酶水平明显低于血压较高的患者。本研究证实多发伤后级联系统很快被激活。
