Chemistry Department, Graham Environmental Sustainability Institute, University of Michigan, Ann Arbor, MI 48109-1055, USA.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2009 Jul-Aug;1(4):353-9. doi: 10.1002/wnan.27.
Nanoparticles arise from a wide variety of natural and man-made sources and have a diverse array of biological, chemical, and physical properties. The toxicity of these particles can be roughly divided into two categories: 1) the enhanced delivery of toxic agents 2) toxicity induced the properties of the particle itself. The use of nanoparticles to provide enhanced delivery of chemotherapeutics is presented followed by a discussion of the size-based effects of electron transfer and physical membrane disruption.
纳米颗粒源自广泛的天然和人为来源，具有多种生物学、化学和物理特性。这些颗粒的毒性大致可以分为两类：1）增强毒性剂的传递；2）由颗粒本身的特性引起的毒性。本文首先介绍了纳米颗粒在增强化疗药物传递方面的应用，然后讨论了基于尺寸的电子转移和物理膜破坏的效应。
