University Hospital Nice, France.
J Eur Acad Dermatol Venereol. 2010 Jan;24(1):22-7. doi: 10.1111/j.1468-3083.2009.03344.x.
The chronic and treatment-resistant nature of nail psoriasis affects patients' lives not only physically but also psychologically. Although there are scoring systems available for disease severity, there is as yet no scale to evaluate the impact of this condition upon the patients' quality of life.
This study aims to develop and validate a quality of life scale specifically for nail psoriasis.
A questionnaire was developed during a study conducted in France between 2004 and 2005. With the cooperation of l'Association Pour la Lutte Contre le Psoriasis, the questionnaire was sent to a random sample of 4000 of its 17,000 members.
The response rate was 33%. Of the 1309 questionnaires returned, 795 showed the presence of nail psoriasis and these were eligible. The scale score is obtained by adding together the responses to the 10 questionnaire items and the result is expressed as a percentage. The value of the score obtained is proportional to the functional difficulty experienced. The determination of Cronbach's a coefficient and a Principal Component Factor Analysis show, respectively, very good internal consistency and the unidimensional nature of the scale. Test-retest results on 15 patients showed good reproducibility. Results were validated with reference to the Dermatology Life Quality Index. In this study, the NPQ10 score is significantly influenced by gender (women have a higher score) and by the duration of psoriasis (recent onset implies greater functional difficulty). Finally, the score is much higher when the nail psoriasis affects both the hands and the feet.
This study confirms a change in the quality of life of patients who have nail psoriasis. The NPQ10 scale, specific to this condition, is simple to use and has the attributes needed in a quality of life scale. The scale must now be tested in longitudinal studies (such as clinical trials) to confirm its ability to measure a change in status.
指甲银屑病的慢性和难治性特征不仅对患者的身体，而且对其心理都产生影响。尽管有疾病严重程度的评分系统，但目前还没有评估该疾病对患者生活质量影响的量表。
本研究旨在开发和验证一种专门针对指甲银屑病的生活质量量表。
在 2004 年至 2005 年期间在法国进行的一项研究中开发了一份调查问卷。在法国银屑病协会的合作下，向其 17000 名成员中的 4000 名随机成员发送了问卷。
应答率为 33%。在返回的 1309 份问卷中，795 份显示存在指甲银屑病，且符合条件。量表评分通过将 10 个问卷项目的回答相加得出，结果以百分比表示。所获得的分数值与功能困难程度成正比。Cronbach's a 系数的确定和主成分因子分析分别显示了该量表的极好的内部一致性和单一维度性质。对 15 名患者的测试-重测结果表明具有良好的可重复性。结果参照皮肤病生活质量指数进行了验证。在本研究中，NPQ10 评分显著受到性别（女性得分更高）和银屑病发病时间（发病时间越短，功能障碍越严重）的影响。最后，指甲银屑病同时影响双手和双脚时，评分会更高。
本研究证实了患有指甲银屑病的患者生活质量发生了变化。针对该疾病的 NPQ10 量表使用简便，具有生活质量量表所需的属性。该量表现在必须在纵向研究（如临床试验）中进行测试，以确认其测量状态变化的能力。
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