Department of Dermatology, Radboud university medical center, Nijmegen, The Netherlands.
Department of Dermatology, Radboud university medical center, Nijmegen, The Netherlands.
J Am Acad Dermatol. 2014 Jun;70(6):1061-6. doi: 10.1016/j.jaad.2014.02.010. Epub 2014 Mar 31.
Scoring systems are indispensable in evaluating the severity of disease and monitoring treatment response.
We sought to evaluate the competence of various nail psoriasis severity scoring systems and to develop a new scoring system.
The authors conducted a prospective, observational, single-point study of 36 patients given the diagnosis of fingernail psoriasis. Seven scoring systems were evaluated: Nail Psoriasis Severity Index (NAPSI), modified NAPSI, target NAPSI, Psoriasis Nail Severity Score, Nail Area Severity, Baran, and Cannavò et al. All tools were correlated with the Physician Global Assessment. Obtained information was integrated into the Nijmegen-Nail psoriasis Activity Index tooL (N-NAIL), and interrater and intrarater reliability was assessed.
Physician Global Assessment showed an acceptable correlation with the scoring system designed by Baran (r = 0.735, P < .01) and the Psoriasis Nail Severity Score (r = 0.734, P < .01). Target NAPSI showed low correlation (r = 0.203, P > .05). The correlation between Physician Global Assessment and the N-NAIL was 0.861 (P < .01). Excellent agreement was found for the intrarater and interrater reliability of the N-NAIL.
Sample size was limited.
An adequate nail psoriasis scoring system is needed, as studies of treatments for nail psoriasis are on the horizon. Clinical severity of nail psoriasis was best reflected by the N-NAIL, followed by the Baran system and the Psoriasis Nail Severity Score.
评分系统在评估疾病严重程度和监测治疗反应方面不可或缺。
我们旨在评估各种指甲银屑病严重程度评分系统的能力,并开发一种新的评分系统。
作者对 36 名确诊为指甲银屑病的患者进行了前瞻性、观察性、单点研究。评估了七种评分系统:指甲银屑病严重程度指数(NAPSI)、改良 NAPSI、目标 NAPSI、银屑病指甲严重程度评分、指甲面积严重程度、Baran 和 Cannavò 等人的评分系统。所有工具均与医生总体评估相关。将获得的信息整合到尼梅根指甲银屑病活动指数工具(N-NAIL)中,并评估了组内和组间的可靠性。
医生总体评估与 Baran 设计的评分系统(r = 0.735,P <.01)和银屑病指甲严重程度评分(r = 0.734,P <.01)具有较好的相关性。目标 NAPSI 相关性较低(r = 0.203,P >.05)。医生总体评估与 N-NAIL 的相关性为 0.861(P <.01)。N-NAIL 的组内和组间可靠性均具有极好的一致性。
样本量有限。
指甲银屑病需要一种足够的评分系统,因为针对指甲银屑病的治疗研究即将开展。指甲银屑病的临床严重程度最好由 N-NAIL、Baran 系统和银屑病指甲严重程度评分来反映。