Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy.
Reprod Biol Endocrinol. 2010 Jan 5;8:1. doi: 10.1186/1477-7827-8-1.
Early pregnancy loss can be associated with trophoblast insufficiency and coagulation defects. Thrombomodulin is an endothelial-associated anticoagulant protein involved in the control of hemostasis and inflammation at the vascular beds and it's also a cofactor of the protein C anticoagulant pathway.
We evaluate the Thrombomodulin expression in placental tissue from spontaneous recurrent miscarriage and voluntary abortion as controls. Thrombomodulin mRNA was determined using real-time quantitative polymerase chain reaction. Reduced expression levels of thrombomodulin were found in recurrent miscarriage group compared to controls (1.82-fold of reduction), that corresponds to a reduction of 45% (from control group Delta CT) of thrombomodulin expression in spontaneous miscarriage group respect the control groups.
We cannot state at present the exact meaning of a reduced expression of Thrombomodulin in placental tissue. Further studies are needed to elucidate the biological pathway of this important factor in the physiopathology of the trophoblast and in reproductive biology.
早期妊娠丢失可能与滋养层功能不全和凝血缺陷有关。血栓调节蛋白是一种内皮相关抗凝蛋白，参与血管床止血和炎症的控制，也是蛋白 C 抗凝途径的辅助因子。
我们评估了习惯性流产和自愿流产作为对照的胎盘组织中血栓调节蛋白的表达。使用实时定量聚合酶链反应测定血栓调节蛋白 mRNA。与对照组相比，习惯性流产组的血栓调节蛋白表达水平降低（降低 1.82 倍），这对应于习惯性流产组相对于对照组血栓调节蛋白表达降低 45%（从对照组 CT 差值）。
目前，我们尚不能确定胎盘组织中血栓调节蛋白表达降低的确切意义。需要进一步研究来阐明这个重要因素在滋养层生理学和生殖生物学中的生物学途径。
