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“健康婴儿”:胚胎植入前遗传学诊断的双重命令。

A 'healthy baby': The double imperative of preimplantation genetic diagnosis.

机构信息

Centre for Biomedicine & Society, King's College London, Strand, London, UK.

出版信息

Health (London). 2010 Jan;14(1):41-56. doi: 10.1177/1363459309347477.

DOI:10.1177/1363459309347477
PMID:20051429
Abstract

This article reports from a study exploring the social processes, meanings and institutions that frame and produce 'ethical problems' and clinical dilemmas for practitioners, scientists and others working in the specialty of preimplantation genetic diagnosis (PGD). A major topic in the data was that, in contrast to IVF, the aim of PGD is to transfer to the woman's womb only those embryos likely to be unaffected by serious genetic disorders; that is, to produce 'healthy babies'. Staff described the complex processes through which embryos in each treatment cycle must meet a double imperative: they must be judged viable by embryologists and 'unaffected' by geneticists. In this article, we focus on some of the ethical, social and occupational issues for staff ensuing from PGD's double imperative.

摘要

本文报道了一项研究,该研究探讨了社会过程、意义和制度,这些过程、意义和制度构成并产生了从业者、科学家和其他从事植入前遗传诊断(PGD)专业工作的人所面临的“伦理问题”和临床困境。数据中的一个主要主题是,与体外受精(IVF)不同,PGD 的目的是仅将那些可能不受严重遗传疾病影响的胚胎转移到女性子宫中;也就是说,要生出“健康的婴儿”。工作人员描述了胚胎在每个治疗周期中必须通过的复杂过程,必须通过胚胎学家判断其是否具有活力,并且必须通过遗传学家判断其是否不受遗传疾病影响。在本文中,我们重点介绍了 PGD 的双重指令给工作人员带来的一些伦理、社会和职业问题。

相似文献

1
A 'healthy baby': The double imperative of preimplantation genetic diagnosis.“健康婴儿”:胚胎植入前遗传学诊断的双重命令。
Health (London). 2010 Jan;14(1):41-56. doi: 10.1177/1363459309347477.
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Choosing embryos: ethical complexity and relational autonomy in staff accounts of PGD.选择胚胎:胚胎植入前遗传学诊断中工作人员描述的伦理复杂性与关系自主性
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Refining the ethics of preimplantation genetic diagnosis: A plea for contextualized proportionality.细化胚胎植入前遗传学诊断的伦理问题:呼吁语境化的相称性。
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Views of internists towards uses of PGD.内科医生对 PGD 使用的看法。
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Ethics of PGD: thoughts on the consequences of typing HLA in embryos.植入前基因诊断的伦理:关于胚胎HLA分型后果的思考。
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Review of patient decision-making factors and attitudes regarding preimplantation genetic diagnosis.对患者在胚胎植入前遗传学诊断方面的决策因素和态度的回顾。
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Challenges, Dilemmas and Factors Involved in PGD Decision-Making: Providers' and Patients' Views, Experiences and Decisions.植入前基因诊断决策中的挑战、困境及相关因素:提供者与患者的观点、经历及决策
J Genet Couns. 2018 Aug;27(4):909-919. doi: 10.1007/s10897-017-0173-9. Epub 2017 Dec 16.
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Is there an ethical difference between preimplantation genetic diagnosis and abortion?胚胎植入前基因诊断与堕胎在伦理上有区别吗?
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引用本文的文献

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Preimplantation Genetic Testing for Adult-Onset Neurodegenerative Disease: Considerations for Access, Utilization, and Counseling.胚胎植入前遗传学检测成人神经退行性疾病:获取、利用和咨询的考虑因素。
Neurology. 2023 Nov 7;101(19):836-841. doi: 10.1212/WNL.0000000000207736. Epub 2023 Aug 18.
2
Dealing with treatment and transfer requests: how PGD-professionals discuss ethical challenges arising in everyday practice.应对治疗与转诊请求:PGD专业人员如何讨论日常实践中出现的伦理挑战。
Med Health Care Philos. 2018 Sep;21(3):375-386. doi: 10.1007/s11019-017-9811-0.
3
Preimplantation genetic diagnosis (PGD) according to medical ethics and medical law.
根据医学伦理和医学法律进行的植入前基因诊断(PGD)。
J Turk Ger Gynecol Assoc. 2012 Mar 1;13(1):50-5. doi: 10.5152/jtgga.2011.72. eCollection 2012.
4
"My funky genetics": BRCA1/2 mutation carriers' understanding of genetic inheritance and reproductive merger in the context of new reprogenetic technologies.“我的奇特基因”:BRCA1/2 突变携带者在新的生殖遗传技术背景下对遗传继承和生殖融合的理解
Fam Syst Health. 2012 Jun;30(2):166-80. doi: 10.1037/a0028434.
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Embryo futures and stem cell research: the management of informed uncertainty.胚胎未来与干细胞研究:知情不确定性的管理。
Sociol Health Illn. 2012 Jan;34(1):114-29. doi: 10.1111/j.1467-9566.2011.01367.x. Epub 2011 Aug 3.