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本文引用的文献

1
Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells.Wnt7a激活平面细胞极性通路以驱动卫星干细胞的对称扩增。
Cell Stem Cell. 2009 Jun 5;4(6):535-47. doi: 10.1016/j.stem.2009.03.013.
2
One-year follow-up of feasibility and safety of the first U.S., randomized, controlled study using 3-dimensional guided catheter-based delivery of autologous skeletal myoblasts for ischemic cardiomyopathy (CAuSMIC study).首项美国随机对照研究的一年随访：使用 3D 引导导管输送自体成肌细胞治疗缺血性心肌病的可行性和安全性（CAuSMIC 研究）。
JACC Cardiovasc Interv. 2009 Jan;2(1):9-16. doi: 10.1016/j.jcin.2008.11.003.
3
Engraftment of mesenchymal stem cells into dystrophin-deficient mice is not accompanied by functional recovery.间充质干细胞植入肌营养不良蛋白缺陷小鼠体内并未伴随功能恢复。
Exp Cell Res. 2009 Sep 10;315(15):2624-36. doi: 10.1016/j.yexcr.2009.05.009. Epub 2009 May 19.
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Further characterisation of the molecular signature of quiescent and activated mouse muscle satellite cells.静止和活化的小鼠肌肉卫星细胞分子特征的进一步表征。
PLoS One. 2009;4(4):e5205. doi: 10.1371/journal.pone.0005205. Epub 2009 Apr 16.
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Enhancement of myogenic and muscle repair capacities of human adipose-derived stem cells with forced expression of MyoD.通过强制表达MyoD增强人脂肪来源干细胞的成肌和肌肉修复能力。
Mol Ther. 2009 Jun;17(6):1064-72. doi: 10.1038/mt.2009.67. Epub 2009 Apr 7.
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A fresh look at iPS cells.对诱导多能干细胞的全新审视。
Cell. 2009 Apr 3;137(1):13-7. doi: 10.1016/j.cell.2009.03.034.
7
Syndecan-4-expressing muscle progenitor cells in the SP engraft as satellite cells during muscle regeneration.在肌肉再生过程中，侧群（SP）中表达Syndecan-4的肌肉祖细胞作为卫星细胞植入。
Cell Stem Cell. 2009 Mar 6;4(3):217-25. doi: 10.1016/j.stem.2009.01.016.
8
Generation of transplantable, functional satellite-like cells from mouse embryonic stem cells.从小鼠胚胎干细胞生成可移植的、功能性卫星样细胞。
FASEB J. 2009 Jun;23(6):1907-19. doi: 10.1096/fj.08-123661. Epub 2009 Jan 23.
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Guidelines and techniques for the generation of induced pluripotent stem cells.诱导多能干细胞生成的指导原则与技术
Cell Stem Cell. 2008 Dec 4;3(6):595-605. doi: 10.1016/j.stem.2008.11.008.
10
Self-renewal and expansion of single transplanted muscle stem cells.单个移植肌肉干细胞的自我更新与扩增
Nature. 2008 Nov 27;456(7221):502-6. doi: 10.1038/nature07384. Epub 2008 Sep 17.

修复骨骼肌：骨骼肌干细胞的再生潜力。

Repairing skeletal muscle: regenerative potential of skeletal muscle stem cells.

机构信息

Division of Regenerative Medicine, San Raffaele Scientific Institute, 58 via Olgettina, Milan, Italy.

出版信息

J Clin Invest. 2010 Jan;120(1):11-9. doi: 10.1172/JCI40373.

DOI:10.1172/JCI40373
PMID:20051632
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2798695/
Abstract

Skeletal muscle damaged by injury or by degenerative diseases such as muscular dystrophy is able to regenerate new muscle fibers. Regeneration mainly depends upon satellite cells, myogenic progenitors localized between the basal lamina and the muscle fiber membrane. However, other cell types outside the basal lamina, such as pericytes, also have myogenic potency. Here, we discuss the main properties of satellite cells and other myogenic progenitors as well as recent efforts to obtain myogenic cells from pluripotent stem cells for patient-tailored cell therapy. Clinical trials utilizing these cells to treat muscular dystrophies, heart failure, and stress urinary incontinence are also briefly outlined.

摘要

受损的骨骼肌或因退行性疾病（如肌肉营养不良症）而损伤的骨骼肌能够再生新的肌肉纤维。再生主要依赖于卫星细胞，即定位于基底膜和肌纤维膜之间的成肌祖细胞。然而，基底膜之外的其他细胞类型，如周细胞，也具有成肌潜能。本文将讨论卫星细胞和其他成肌祖细胞的主要特性，以及为了从多能干细胞获得用于个体化细胞治疗的成肌细胞而开展的最新研究。本文还简要概述了利用这些细胞治疗肌肉萎缩症、心力衰竭和压力性尿失禁的临床试验。