修复骨骼肌：骨骼肌干细胞的再生潜力。
Repairing skeletal muscle: regenerative potential of skeletal muscle stem cells.
机构信息
Division of Regenerative Medicine, San Raffaele Scientific Institute, 58 via Olgettina, Milan, Italy.
出版信息
J Clin Invest. 2010 Jan;120(1):11-9. doi: 10.1172/JCI40373.
Abstract
Skeletal muscle damaged by injury or by degenerative diseases such as muscular dystrophy is able to regenerate new muscle fibers. Regeneration mainly depends upon satellite cells, myogenic progenitors localized between the basal lamina and the muscle fiber membrane. However, other cell types outside the basal lamina, such as pericytes, also have myogenic potency. Here, we discuss the main properties of satellite cells and other myogenic progenitors as well as recent efforts to obtain myogenic cells from pluripotent stem cells for patient-tailored cell therapy. Clinical trials utilizing these cells to treat muscular dystrophies, heart failure, and stress urinary incontinence are also briefly outlined.
摘要
受损的骨骼肌或因退行性疾病（如肌肉营养不良症）而损伤的骨骼肌能够再生新的肌肉纤维。再生主要依赖于卫星细胞，即定位于基底膜和肌纤维膜之间的成肌祖细胞。然而，基底膜之外的其他细胞类型，如周细胞，也具有成肌潜能。本文将讨论卫星细胞和其他成肌祖细胞的主要特性，以及为了从多能干细胞获得用于个体化细胞治疗的成肌细胞而开展的最新研究。本文还简要概述了利用这些细胞治疗肌肉萎缩症、心力衰竭和压力性尿失禁的临床试验。
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