再生医学：心血管再生生物学中的发育范式。
Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration.
机构信息
Cardiovascular Research Center, Massachusetts General Hospital, Charles River Plaza/CPZN 3200, 185 Cambridge Street, Boston, MA 02114-2790, USA.
出版信息
J Clin Invest. 2010 Jan;120(1):20-8. doi: 10.1172/JCI40820.
Abstract
The ability to create new functional cardiomyocytes is the holy grail of cardiac regenerative medicine. From studies using model organisms, new insights into the fundamental pathways that drive heart muscle regeneration have begun to arise as well as a growing knowledge of the distinct families of multipotent cardiovascular progenitors that generate diverse lineages during heart development. In this Review, we highlight this intersection of the "pregenerative" biology of heart progenitor cells and heart regeneration and discuss the longer term challenges and opportunities in moving toward a therapeutic goal of regenerative cardiovascular medicine.
摘要
生成新的功能性心肌细胞的能力是心脏再生医学的圣杯。通过使用模式生物进行研究，人们开始深入了解驱动心肌再生的基本途径，以及在心脏发育过程中产生多种谱系的多能心血管祖细胞的不同家族。在这篇综述中，我们强调了心脏祖细胞的“再生前”生物学与心脏再生之间的这一交叉点，并讨论了在朝着再生心血管医学的治疗目标前进方面所面临的长期挑战和机遇。
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