血管生成。新生心脏中独特冠状动脉群体的从头形成。
Vessel formation. De novo formation of a distinct coronary vascular population in neonatal heart.
机构信息
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
Zhongshan Hospital, Fudan University, Shanghai 200032, China.
出版信息
Science. 2014 Jul 4;345(6192):90-4. doi: 10.1126/science.1251487.
The postnatal coronary vessels have been viewed as developing through expansion of vessels formed during the fetal period. Using genetic lineage tracing, we found that a substantial portion of postnatal coronary vessels arise de novo in the neonatal mouse heart, rather than expanding from preexisting embryonic vasculature. Our data show that lineage conversion of neonatal endocardial cells during trabecular compaction generates a distinct compartment of the coronary circulation located within the inner half of the ventricular wall. This lineage conversion occurs within a brief period after birth and provides an efficient means of rapidly augmenting the coronary vasculature. This mechanism of postnatal coronary vascular growth provides avenues for understanding and stimulating cardiovascular regeneration following injury and disease.
出生后的冠状动脉血管被认为是通过胎儿期形成的血管扩张而发育的。通过遗传谱系追踪，我们发现新生小鼠心脏中的大部分出生后冠状动脉血管是从头开始形成的，而不是从现有的胚胎血管扩张而来。我们的数据表明，小梁化期间新生儿心内膜细胞的谱系转换会在心室壁的内半部分生成一个独特的冠状动脉循环区室。这种谱系转换发生在出生后很短的时间内，并提供了一种有效的快速增加冠状动脉血管的方法。这种出生后冠状动脉血管生长的机制为理解和刺激损伤和疾病后的心血管再生提供了途径。
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