Institute of Cardiology, Kaunas University of Medicine, Kaunas, Lithuania.
Medicina (Kaunas). 2009;45(11):904-9.
The objective of study was to estimate the importance of maternal socioeconomic and lifestyle factors during pregnancy in the risk of congenital heart defects in Kaunas infant population in 1999-2005.
An epidemiological case-control study was conducted. The study comprised 187 newborns with congenital heart defects (cases) and 643 randomly selected newborns without any defects (controls), born in Kaunas city during 1999-2005. Modern epidemiological methods were used for data analysis. A multivariate logistic regression was used to determine adjusted risk factors of congenital heart defects.
The logistic multivariate regression analysis showed that low and moderate maternal education significantly increased the risk of congenital heart defects (primary or basic [OR=3.43; 95% CI, 1.54-7.64] and secondary [OR=1.56; 95% CI, 1.00-2.45] vs advanced vocational or higher education). The housewives and workers had a higher risk of delivering a newborn with congenital heart defects than the office workers (OR=2.34; 95% CI, 1.34-4.10 and OR=1.28; 95% CI, 0.79-2.07, respectively). Maternal smoking during pregnancy tended to increase the risk of congenital heart defects by 48% (OR=1.48; 95% CI, 0.82-2.67).
According to our study results, unfavorable maternal socioeconomic factors and smoking during pregnancy increased the risk of congenital heart defects.
研究旨在评估母亲在妊娠期间的社会经济和生活方式因素对 1999-2005 年考纳斯婴儿群体先天性心脏病风险的重要性。
进行了一项流行病学病例对照研究。该研究纳入了 1999-2005 年期间在考纳斯市出生的 187 名先天性心脏病新生儿（病例）和 643 名随机选择的无任何缺陷的新生儿（对照）。采用现代流行病学方法进行数据分析。多变量逻辑回归用于确定先天性心脏病的调整风险因素。
多变量逻辑回归分析显示，母亲的低等和中等教育程度显著增加了先天性心脏病的风险（初等或基础教育[OR=3.43；95%CI，1.54-7.64]和中等职业或更高教育[OR=1.56；95%CI，1.00-2.45]）。家庭主妇和工人与上班族相比，生育先天性心脏病新生儿的风险更高（OR=2.34；95%CI，1.34-4.10 和 OR=1.28；95%CI，0.79-2.07）。母亲在妊娠期间吸烟的行为可能会使先天性心脏病的风险增加 48%（OR=1.48；95%CI，0.82-2.67）。
根据我们的研究结果，不利的母亲社会经济因素和妊娠期间吸烟会增加先天性心脏病的风险。
