Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky 40536-0200, USA.
Curr Opin Nephrol Hypertens. 2010 Mar;19(2):195-200. doi: 10.1097/MNH.0b013e3283366cd0.
In contrast to previous understanding, adipocytes are now known to produce an array of factors collectively termed 'adipokines', several of which have effects on the cardiovascular system. The marked rise in prevalence of obesity warrants investigation into the role of adipocyte-derived factors in the regulation of blood pressure. For example, dysregulated production of specific adipokines in the setting of obesity may contribute to hypertension commonly experienced in obese patients. This editorial highlights current concepts for regulation of adipokine production by adipocytes and their potential role in blood pressure regulation.
Adipocytes synthesize and release several factors that have been linked to blood pressure control, including adiponectin, leptin, angiotensin, perivascular relaxation factors and resistin. Increasing evidence suggests that aberrant production and release of these factors from adipocytes may contribute to the high prevalence of hypertension in the obese population. However, additional studies are warranted to define precise mechanisms for blood pressure regulation by these factors, and to delineate their role in obesity-related hypertension.
Studies aimed at determining the role of adipocyte-derived factors in blood pressure regulation during normal physiology and in the setting of obesity are needed.
综述目的：与之前的认识相反，脂肪细胞现在被认为会产生一系列被统称为“脂肪因子”的物质，其中一些对心血管系统有影响。肥胖症的发病率显著上升，这就需要研究脂肪细胞衍生因子在调节血压中的作用。例如，肥胖症中特定脂肪因子的失调产生可能导致肥胖患者常见的高血压。本社论重点介绍了脂肪细胞调节脂肪因子产生的最新概念及其在血压调节中的潜在作用。
最新发现：脂肪细胞合成和释放了几种与血压控制有关的因子，包括脂联素、瘦素、血管紧张素、血管周围松弛因子和抵抗素。越来越多的证据表明，这些因子从脂肪细胞中的异常产生和释放可能导致肥胖人群中高血压的高发病率。然而，还需要进一步的研究来确定这些因子对血压调节的确切机制，并阐明它们在肥胖相关高血压中的作用。
总结：需要研究旨在确定脂肪细胞衍生因子在正常生理和肥胖症情况下调节血压中的作用。
