Liao Jia, Qiu Miaohan, Li Jing, Li Yi, Han Yaling
State Key Laboratory of Frigid Zone Cardiovascular Disease, Department of cardiovascular, General Hospital of Northern Theater Command, Shenyang, China.
Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
J Clin Hypertens (Greenwich). 2025 Jan;27(1):e14953. doi: 10.1111/jch.14953. Epub 2024 Dec 10.
The causal relationship between visceral adipose tissue (VAT) and hypertension remains unclear. We aimed to examine the potential association between them using observational and two-sample Mendelian randomization (MR) analyses. Data from the National Health and Nutrition Examination Survey (NHANES) 2011-2018 were used, applying multivariable logistic regression analysis to investigate the association between VAT mass and hypertension risk. Independent genetic variants related to VAT mass were derived from genome-wide association studies (GWAS) in 325 153 UK Biobank participants. The primary analysis employed the random-effects inverse-variance weighted (IVW) method, with MR-Egger, weighted median, simple mode, and weighted mode as sensitivity analyses. A total of 7661 participants were included. After adjusting for confounding factors, increased VAT mass was associated with a higher risk of hypertension (quartile 4 vs. quartile 1: OR:1.85, 95% confidence intervals [CI]: 1.31-2.63). Furthermore, VAT mass exhibited greater accuracy than body mass index (BMI) in predicting hypertension (areas under the curve [AUC]: 0.701 vs. 0.676, p for comparison < 0.001). The MR analyses demonstrated a causal relationship between increased VAT mass and the risk of hypertension in primary analyses (odds ratio [OR]:1.768, 95% CI: 1.594-1.861). Consistent findings across various MR models substantiate the robustness and strength of this causal relationship. These analyses provide additional support for both the positive association and causal relationship between elevated VAT and the risk of developing hypertension, suggesting that targeted interventions for VAT may be beneficial in preventing hypertension.
内脏脂肪组织（VAT）与高血压之间的因果关系仍不明确。我们旨在通过观察性分析和两样本孟德尔随机化（MR）分析来研究它们之间的潜在关联。使用了2011 - 2018年美国国家健康与营养检查调查（NHANES）的数据，应用多变量逻辑回归分析来研究VAT量与高血压风险之间的关联。与VAT量相关的独立基因变异来自对325153名英国生物银行参与者的全基因组关联研究（GWAS）。主要分析采用随机效应逆方差加权（IVW）方法，以MR-Egger、加权中位数、简单模式和加权模式作为敏感性分析。共纳入7661名参与者。在调整混杂因素后，VAT量增加与高血压风险升高相关（四分位数4与四分位数1相比：比值比[OR]：1.85，95%置信区间[CI]：1.31 - 2.63）。此外，在预测高血压方面，VAT量比体重指数（BMI）表现出更高的准确性（曲线下面积[AUC]：0.701对0.676，比较p值<0.001）。MR分析在主要分析中证明了VAT量增加与高血压风险之间存在因果关系（比值比[OR]：1.768，95% CI：1.594 - 1.861）。各种MR模型的一致结果证实了这种因果关系的稳健性和强度。这些分析为VAT升高与高血压发生风险之间的正相关和因果关系提供了额外支持，表明针对VAT的靶向干预可能有助于预防高血压。
