INSERM U970, Paris Cardiovascular Research Center-PARCC, Paris, France.
Curr Opin Nephrol Hypertens. 2010 Mar;19(2):177-80. doi: 10.1097/MNH.0b013e32833640fd.
To summarize the potential role of microparticles in hypertension and in cardiovascular diseases. Microparticles are submicron vesicles shed from the membrane in response to cell activation or apoptosis. Microparticles of different cellular origins are found in the plasma of healthy individuals and their circulating levels augment in patients with cardiovascular diseases.
Recent studies demonstrate that circulating levels of microparticles originating from endothelial cells, which represent a small fraction of the overall pool of plasma microparticles, augment with increased endothelial dysfunction in patients with cardiovascular diseases. Therefore, endothelial microparticles constitute an emerging surrogate marker of endothelial dysfunction, with potential prognostic value for major adverse events in patients with cardiovascular diseases. In addition, microparticles of endothelial and other cellular origins are also potential biological effectors in inflammation, vascular injury, angiogenesis and thrombosis.
In summary, circulating endothelial microparticles may serve not only as an index of arterial damage but also as a trigger of vascular repair.
总结微粒在高血压和心血管疾病中的潜在作用。微粒是细胞激活或凋亡时从细胞膜上脱落的亚微米囊泡。不同细胞来源的微粒存在于健康个体的血浆中，其循环水平在心血管疾病患者中增加。
最近的研究表明，来源于内皮细胞的循环微粒水平随着心血管疾病患者内皮功能障碍的增加而增加，而内皮细胞微粒仅占血浆微粒总体池的一小部分。因此，内皮微粒是内皮功能障碍的新兴替代标志物，对心血管疾病患者的主要不良事件具有潜在的预后价值。此外，内皮和其他细胞来源的微粒也是炎症、血管损伤、血管生成和血栓形成的潜在生物效应物。
总之，循环内皮微粒不仅可以作为动脉损伤的指标，还可以作为血管修复的触发因素。
