INSERM, U970, Paris Cardiovascular Research Center - PARCC, Paris, France.
Semin Thromb Hemost. 2010 Nov;36(8):907-16. doi: 10.1055/s-0030-1267044. Epub 2010 Nov 10.
Microparticles (MP) are shed membrane vesicles released by various cell types following apoptosis or activation. MP circulate in human plasma and also accumulate in atherosclerotic lesions. A growing body of evidence has highlighted their involvement in inflammation, angiogenesis, coagulation, and the regulation of vascular tone. MP may therefore contribute to the initiation and development of atherosclerosis and its complications. Plasma MP originate from platelets, leukocytes, erythrocytes, and endothelial cells, and their levels increase in patients with cardiovascular diseases; specific cardiovascular medications also affect plasma MP levels. Most recent data suggest a potential prognostic role of circulating MP for identification of subjects prone to develop cardiovascular complications.
微粒（MP）是各种细胞在凋亡或激活后释放的膜小泡。MP 存在于人体血浆中，并在动脉粥样硬化病变中积累。越来越多的证据强调了它们在炎症、血管生成、凝血和血管张力调节中的作用。因此，MP 可能有助于动脉粥样硬化及其并发症的发生和发展。血浆 MP 来源于血小板、白细胞、红细胞和内皮细胞，心血管疾病患者的血浆 MP 水平升高；特定的心血管药物也会影响血浆 MP 水平。最新数据表明，循环 MP 对识别易发生心血管并发症的患者具有潜在的预后作用。
