HIV-NAT, the Thai Red Cross AIDS Research Center, Bangkok, Thailand.
J Neurovirol. 2010 Feb;16(1):76-82. doi: 10.3109/13550280903493914.
This research is a cross-sectional study to determine the frequency of neurocognitive impairment and psychiatric comorbidity among Thais maintained on highly active antiretroviral therapy (HAART) with undetectable plasma human immunodeficiency virus (HIV) RNA in the 2NN Cohort. Sixty-four subjects were evaluated with neurological examinations, neuropsychological testing, and psychiatric questionnaires. Twenty-four subjects (37.5%) were found to have neurocognitive impairment, with 13 (20.3%), 10 (15.6%), and 1 (1.6%) classified as asymptomatic neurocognitive disorder (ANI), mild neurocognitive disorder (MND), and HIV-associated dementia (HAD), respectively. Three subjects (4.7%) had depression and no cases had significant symptoms of anxiety. A notable proportion of well-controlled individuals exhibited neurocognitive impairment. Anxiety and depression were uncommon.
本研究是一项横断面研究，旨在确定在 2NN 队列中接受高效抗逆转录病毒治疗（HAART）且血浆人类免疫缺陷病毒（HIV）RNA 不可检测的泰国人出现神经认知障碍和精神共病的频率。对 64 名受试者进行了神经系统检查、神经心理学测试和精神问卷评估。24 名受试者（37.5%）存在神经认知障碍，其中 13 名（20.3%）、10 名（15.6%）和 1 名（1.6%）分别归类为无症状性神经认知障碍（ANI）、轻度神经认知障碍（MND）和 HIV 相关性痴呆（HAD）。3 名受试者（4.7%）患有抑郁症，无焦虑显著症状。相当一部分控制良好的个体存在神经认知障碍。焦虑和抑郁并不常见。
