Department of Otolaryngology, Gifu University Graduate School of Medicine, Gifu, Japan.
Int J Audiol. 2010 Jan;49(1):1-6. doi: 10.3109/14992020903160850.
An elevation of the plasma arginine vasopressin (AVP) level has frequently been observed in Meniere's disease patients. However, little is known regarding the mechanism behind this elevation. The plasma AVP levels in acute phase were determined in 21 Meniere's disease patients and 16 patients with other types of vertigo. The plasma AVP levels of Meniere's disease patients in the acute phase were significantly higher than in those of other vertigo patients (p < 0.01). In Meniere's disease patients with abnormally high levels of AVP (more than 3.5 pg/ml) in the acute phase, 36% of patients were resistant to conservative treatments for frequent vertigo attacks for the follow-up period of at least 2years. A significant correlation was observed between the plasma AVP in the acute phase and the highest hearing threshold level at a frequency of 1kHz for the follow-up period of at least 1 year (r=0.45, p < 0.05). These results suggest that the elevation in plasma AVP level in the acute phase is associated with the prognosis of Meniere's disease.
血浆精氨酸加压素（AVP）水平升高在梅尼埃病患者中经常观察到。然而，对于这种升高的背后机制知之甚少。在 21 例梅尼埃病患者和 16 例其他类型眩晕患者的急性期确定了血浆 AVP 水平。急性期梅尼埃病患者的血浆 AVP 水平明显高于其他眩晕患者（p < 0.01）。在急性期 AVP 水平异常升高（超过 3.5 pg/ml）的梅尼埃病患者中，36%的患者在至少 2 年的随访期间对频繁眩晕发作的保守治疗有抵抗。在至少 1 年的随访期间，急性期血浆 AVP 与 1kHz 频率的最高听阈水平之间存在显著相关性（r=0.45，p < 0.05）。这些结果表明，急性期血浆 AVP 水平升高与梅尼埃病的预后有关。
