神经钙黏蛋白-1 基因与儿童 1 型糖尿病的遗传相关性：神经钙黏蛋白-1 在胰岛中的表达。
Genetic association of the neuropilin-1 gene with type 1 diabetes in children: Neuropilin-1 expression in pancreatic islets.
机构信息
Childrens Diabetes Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
出版信息
Diabetes Res Clin Pract. 2010 Mar;87(3):e29-32. doi: 10.1016/j.diabres.2009.12.016. Epub 2010 Jan 6.
Abstract
Minor alleles of two SNPs in intron 9 of the NRP1 gene, which encodes neuropilin-1, were found to be associated with type 1 diabetes (T1D) in children. Neuropilin-1 peptides were confined to islets in human pancreas. This suggests neuropilins-1 could influence the development of some cases of T1D in children.
摘要
在编码神经纤毛蛋白-1（neuropilin-1）的 NRPI 基因 9 号内含子中的两个 SNP 的次要等位基因，与儿童 1 型糖尿病（T1D）有关。神经纤毛蛋白-1 肽局限于人胰腺中的胰岛。这表明神经纤毛蛋白-1 可能影响某些儿童 T1D 的发展。
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