Department of Pediatrics, Copenhagen University Hospital Glostrup, Copenhagen, Denmark.
Obes Facts. 2009;2(4):243-8. doi: 10.1159/000226619. Epub 2009 Jul 20.
This study assessed if lower than predicted serum leptin concentrations seen during weight loss persisted during weight regain, with possible implications for weight control.
115 children were investigated during a 12-week weight loss program. 90 children completed the program, and 68 children entered a follow-up program spanning 28 months. Measurements were performed at baseline and day 82 as well as at months 10, 16, and 28. Height, weight, body composition, Tanner stages, testicular size, and serum concentrations of leptin, and insulin were measured at all time points.
Children with the greatest increases in BMI standard deviation score (SDS) exhibited the largest leptin increments. The disproportionate reduction of leptin seen during weight loss recovered after weight loss. Leptin increases mirrored increases in BMI SDS during weight regain, and the leptin-BMI SDS relationship seen during follow-up resembled the baseline leptin-BMI SDS relationship.
Proportional increases of leptin and BMI SDS during weight regain suggests an intact leptin response during re-accumulation of fat. Following the pronounced reduction of leptin during weight loss, leptin levels were restored during weight regain to an extent where leptin levels were comparable with those at baseline, which is indicative of an inefficient lipostatic control exerted by leptin during weight regain.
本研究评估了在体重反弹期间，体重减轻期间观察到的低于预测的血清瘦素浓度是否持续存在，这可能对体重控制有影响。
115 名儿童在为期 12 周的减肥计划中接受了调查。90 名儿童完成了该计划，其中 68 名儿童进入了为期 28 个月的随访计划。在基线和第 82 天以及第 10、16 和 28 个月时进行了测量。在所有时间点都测量了身高、体重、身体成分、Tanner 阶段、睾丸大小以及血清瘦素和胰岛素浓度。
BMI 标准差评分（SDS）增加最大的儿童表现出最大的瘦素增加。在体重减轻期间观察到的瘦素不成比例减少在体重减轻后得到恢复。在体重反弹期间，瘦素的增加与 BMI SDS 的增加相吻合，而在随访期间观察到的瘦素-BMI SDS 关系类似于基线时的瘦素-BMI SDS 关系。
在体重恢复期间，瘦素和 BMI SDS 的比例增加表明脂肪重新积累期间瘦素反应完整。在体重减轻期间瘦素明显减少后，在体重恢复期间，瘦素水平得到恢复，达到与基线水平相当的程度，这表明在体重恢复期间，瘦素对脂肪的脂控作用效率低下。
