The Children's Obesity Clinic, Department of Paediatrics, Holbæk University Hospital, Holbæk, Denmark.
Obes Facts. 2011;4(6):461-8. doi: 10.1159/000335121. Epub 2011 Dec 6.
To investigate changes in leptin and soluble leptin receptor (SLR) concentrations, and in the free leptin index (FLI) during weight loss and subsequent weight regain; and to ascertain whether these indices remain stable in the rank of the distribution in repeated measures (tracking) during perturbations of weight in obese children.
In a longitudinal study, 115 obese children were examined during a 12- week weight loss programme and 28 months of follow-up. Height, weight, body composition, Tanner stages, testicular size, time of menarche, and concentrations of leptin and SLR were measured at baseline, on days 14, 33, and 82, and from months 10, 16, and 28.
During weight loss, leptin decreased and the SLR increased. During weight regain, leptin increased and the SLR decreased. The partial correlation coefficients expressing the relationship between leptin and SLR were significant in girls during both weight loss and weight regain, whereas in boys they were much weaker and not significant. Leptin, SLR and FLI exhibited individual-specific levels (tracking) during weight loss and regain in boys and girls. The observed tracking seemed stronger during weight loss than during weight regain. The observed tracking was independent of both baseline body mass index (BMI) standard deviation score (SDS) and pubertal development at baseline and of subsequent changes in BMI SDS and puberty stages.
Leptin and the SLR exhibit tracking during weight loss and regain, which indicates individual stability in the leptin system despite challenges of weight.
研究肥胖儿童体重减轻及随后体重反弹过程中瘦素和可溶性瘦素受体（SLR）浓度以及游离瘦素指数（FLI）的变化情况，并确定这些指数在体重波动时的重复测量（跟踪）分布等级中是否保持稳定。
在一项纵向研究中，对 115 名肥胖儿童进行了为期 12 周的减重计划和 28 个月的随访检查。在基线、第 14、33 和 82 天，以及第 10、16 和 28 个月时，测量了身高、体重、身体成分、Tanner 分期、睾丸大小、初潮时间和瘦素及 SLR 浓度。
在减重过程中，瘦素降低，SLR 升高。在体重反弹过程中，瘦素增加，SLR 下降。在女孩的体重减轻和体重恢复期间，瘦素和 SLR 之间的关系的偏相关系数均具有统计学意义，而在男孩中，这些系数较弱且无统计学意义。在男孩和女孩中，瘦素、SLR 和 FLI 在减重和恢复期间表现出个体特异性水平（跟踪）。与体重恢复相比，观察到的跟踪在减重期间更强。观察到的跟踪与基线 BMI 标准差评分（SDS）和基线时的青春期发育以及随后 BMI SDS 和青春期阶段的变化无关。
瘦素和 SLR 在体重减轻和恢复期间表现出跟踪现象，这表明尽管存在体重挑战，但瘦素系统具有个体稳定性。
