Department of Oncology, The Affiliated Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing, 210006, People's Republic of China.
Breast Cancer Res Treat. 2010 Jul;122(2):527-31. doi: 10.1007/s10549-009-0723-4. Epub 2010 Jan 7.
The functional Ser326Cys polymorphism in the human 8-oxogunaine DNA glycosylase (hOGG1) gene has been implicated in breast cancer risk. However, the published findings are inconsistent. We therefore performed a meta-analysis to investigate this relationship. Eleven published case-control studies, including 6,804 breast cancer cases and 6,725 controls were identified. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association. Overall, no significant associations between the hOGG1 Ser326Cys polymorphism and breast cancer risk were found for Cys/Cys versus Ser/Ser (OR = 1.07, 95% CI: 0.94-1.20), Ser/Cys versus Ser/Ser (OR = 0.99, 95% CI: 0.91-1.07), Cys/Cys + Ser/Cys versus Ser/Ser (OR = 1.00, 95% CI = 0.93-1.08), and Cys/Cys versus Ser/Cys + Ser/Ser (OR = 1.07, 95% CI: 0.97-1.18). In the stratified analysis by ethnicity, source of controls, and menopausal status, significant associations were still not observed in all genetic models. Taken together, the results suggest that the hOGG1 Ser326Cys polymorphism is not associated with breast cancer risk.
人类 8-氧鸟嘌呤 DNA 糖基化酶（hOGG1）基因中的功能性 Ser326Cys 多态性与乳腺癌风险有关。然而，已发表的研究结果并不一致。因此，我们进行了一项荟萃分析来研究这种关系。共确定了 11 项已发表的病例对照研究，包括 6804 例乳腺癌病例和 6725 例对照。比值比（OR）和 95%置信区间（CI）用于评估关联的强度。总体而言，hOGG1 Ser326Cys 多态性与乳腺癌风险之间没有显著关联，Cys/Cys 与 Ser/Ser 相比（OR = 1.07，95%CI：0.94-1.20），Ser/Cys 与 Ser/Ser 相比（OR = 0.99，95%CI：0.91-1.07），Cys/Cys + Ser/Cys 与 Ser/Ser 相比（OR = 1.00，95%CI = 0.93-1.08），Cys/Cys 与 Ser/Cys + Ser/Ser 相比（OR = 1.07，95%CI：0.97-1.18）。在按种族、对照来源和绝经状态进行的分层分析中，所有遗传模型均未观察到显著关联。综上所述，结果表明 hOGG1 Ser326Cys 多态性与乳腺癌风险无关。
