hOGG1 基因 Ser326Cys 多态性与胃癌风险相关：来自 1180 例病例和 2444 例对照的证据。

The functional Ser326Cys polymorphism in hOGG1 is associated with gastric cancer risk: evidence from 1180 cases and 2444 controls.

机构信息

Department of Surgery, The Third Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, People's Republic of China.

出版信息

Eur J Gastroenterol Hepatol. 2012 Jun;24(6):683-7. doi: 10.1097/MEG.0b013e328351d1c0.

DOI:10.1097/MEG.0b013e328351d1c0

PMID:22343785

Abstract

BACKGROUND

The functional Ser326Cys polymorphism in the human 8-oxoguanine DNA glycosylase (hOGG1) gene has been implicated in gastric cancer risk. However, the published findings are inconsistent. We therefore carried out a meta-analysis to investigate this relationship.

METHODS

Nine published case-control studies, including 1180 gastric cancer cases and 2444 controls, were identified. Odds ratios and 95% confidence intervals were used to assess the strength of the association.

RESULTS

Overall, the hOGG1 Ser326Cys polymorphism was significantly associated with an increased risk of gastric cancer in a recessive model (Cys/Cys vs. Ser/Cys+Ser/Ser: odds ratio=1.31, 95% confidence interval: 1.03-1.67). In the stratified analysis, a significant association was also observed among Asian populations and hospital-based controls. However, when stratified by smoking status of gastric cancer patients, no statistically significant result was found.

CONCLUSION

Taken together, the results suggest that the hOGG1 Ser326Cys polymorphism may contribute to susceptibility to gastric cancer.

摘要

背景

人类 8-氧鸟嘌呤 DNA 糖基化酶（hOGG1）基因中的功能性 Ser326Cys 多态性与胃癌风险有关。然而，已发表的研究结果并不一致。因此，我们进行了一项荟萃分析来研究这种关系。

方法

确定了 9 项已发表的病例对照研究，包括 1180 例胃癌病例和 2444 例对照。使用优势比和 95%置信区间来评估关联的强度。

结果

总体而言，hOGG1 Ser326Cys 多态性与胃癌的风险增加呈显著相关，在隐性模型中（Cys/Cys 与 Ser/Cys+Ser/Ser：优势比=1.31，95%置信区间：1.03-1.67）。在分层分析中，在亚洲人群和医院为基础的对照组中也观察到了显著的相关性。然而，当按胃癌患者的吸烟状况分层时，没有发现统计学上显著的结果。