Institute of Cancer Prevention and Treatment, Harbin Medical University, Baojian Road 6, Nangang District, 150081 Harbin, China.
Breast Cancer Res Treat. 2010 Aug;122(3):835-42. doi: 10.1007/s10549-009-0722-5. Epub 2010 Jan 8.
It was reported that the functional polymorphism Ser326Cys in the human 8-oxoguanine DNA glycosylase gene was associated with breast cancer risk; however, the published studies have inconsistent conclusions. To elucidate the effect of hOGG1 Ser326Cys on the susceptibility to breast cancer, all available studies were collected in this meta-analysis. We extracted the data from 10 case-control studies that were published in the PubMed database from 2003 to 2008 using the search phrases "human 8-oxoguanine DNA glycosylase, hOGG1, OGG1, OGG, polymorphism, genetic variation, and breast cancer." This meta-analysis included 4,963 breast cancer cases and 4,776 control subjects. The results showed that individuals who carrying the hOGG1 326Cys allele in the additive model did not have significantly increased risk of breast cancer compared with those carrying the 326Ser allele (P = 0.47, OR = 1.02; 95% CI = 0.96-1.09); similarly, no significant association between the hOGG1 326Cys allele and breast cancer risk was found either in the recessive genetic model (P = 0.34, OR = 1.06; 95% CI = 0.94-1.18) for Cys/Cys versus Ser/Cys + Ser/Ser, or dominant genetic model (P = 0.78, OR = 1.01; 95% CI = 0.93-1.11) for Cys/Cys + Ser/Cys versus Ser/Ser. In the stratified analysis, the meta-analysis showed the association between hOGG1 326Cys allele in the additive model and breast cancer was significant in European subjects (P = 0.04, OR = 0.71; 95% CI = 0.51-0.98), and dominant genetic model (P = 0.004, OR = 0.44; 95% CI = 0.25-0.77). However, the association was not significant between this polymorphism and different menopausal status (premenopausal and postmenopausal) and the other ethnicities (Asians and Americans). The meta-analysis suggested that the hOGG1 326Cys allele plays a significant protective effect to breast cancer in European women.
据报道，人类 8-氧鸟嘌呤 DNA 糖基化酶基因中的功能性多态性 Ser326Cys 与乳腺癌风险相关；然而，已发表的研究结论并不一致。为了阐明 hOGG1 Ser326Cys 对乳腺癌易感性的影响，本荟萃分析纳入了所有可用的研究。我们从 2003 年至 2008 年在 PubMed 数据库中使用“human 8-oxoguanine DNA glycosylase, hOGG1, OGG1, OGG, polymorphism, genetic variation, and breast cancer”这些检索词检索到 10 项病例对照研究，并从中提取数据。该荟萃分析共纳入了 4963 例乳腺癌病例和 4776 例对照。结果显示，在加性模型中，携带 hOGG1 326Cys 等位基因的个体与携带 326Ser 等位基因的个体相比，乳腺癌发病风险无显著增加（P=0.47，OR=1.02；95%CI=0.96-1.09）；同样，在隐性遗传模型（P=0.34，OR=1.06；95%CI=0.94-1.18）中，Cys/Cys 与 Ser/Cys+Ser/Ser 相比，以及在显性遗传模型（P=0.78，OR=1.01；95%CI=0.93-1.11）中，Cys/Cys+Ser/Cys 与 Ser/Ser 相比，hOGG1 326Cys 等位基因与乳腺癌风险之间也未发现显著关联。在分层分析中，加性模型的荟萃分析显示，hOGG1 326Cys 等位基因与欧洲人群乳腺癌之间存在显著关联（P=0.04，OR=0.71；95%CI=0.51-0.98），在显性遗传模型中（P=0.004，OR=0.44；95%CI=0.25-0.77）也存在显著关联。然而，这种多态性与不同的绝经状态（绝经前和绝经后）和其他种族（亚洲人和美国人）之间没有显著关联。该荟萃分析表明，在欧洲女性中，hOGG1 326Cys 等位基因对乳腺癌具有显著的保护作用。
