人8-氧代鸟嘌呤DNA糖基化酶1（hOGG1）丝氨酸326位密码子突变为半胱氨酸（Ser326Cys）多态性与肝细胞癌易感性的关联

Association of hOGG1 Ser326Cys polymorphism with susceptibility to hepatocellular carcinoma.

作者信息

Guo Jun, Yang Jing, Li Yan

机构信息

Department of Clinical Laboratory, Renmin Hospital of Wuhan University Wuhan 430060, Hubei, China.

Department of Microbiology, School of Basic Medical Sciences, Hubei University of Medicine Shiyan 442000, Hubei, China.

出版信息

Int J Clin Exp Med. 2015 Jun 15;8(6):8977-85. eCollection 2015.

PMID:26309550

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4537974/

Abstract

BACKGROUND

Since, the relationship between hOGG1 Ser326Cys polymorphism and HCC was inconsistent in the recent literatures. The present meta-analysis based on previous studies was to obtain precise estimation on the issue.

METHODS

A computer search was carried out from PubMed, CBM and EMBASE databases. A total of nine case-control publications with 2583 HCC patients and 2271 controls were included in the meta-analysis. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the relationship of Ser326Cys polymorphism and HCC susceptibility. Z test was used to assess the significance of pooled OR. The fixed-effect model or random-effect model was employed according to heterogeneity.

RESULTS

Overall, hOGG1 Ser326Cys polymorphism was in relation with increased risk for HCC under the following genetic models: GG versus CC: OR=2.51, 95% CI=1.67-3.78; GG versus CG + CC: OR=2.27, 95% CI=1.57-3.30; GG + CG versus CC: OR=1.13, 95% CI=1.03-1.24. The subgroup analysis by ethnicity suggested that high risk for HCC was observed in Asians with GG and GG + CG genotype (GG versus CC: OR=2.17, 95% CI=1.49-3.17; GG versus CG + CC: OR=1.96, 95% CI=1.41-2.73; GG + CG versus CC: OR=1.13, 95% CI=1.03-1.25). For subgroup analysis based on source of control, GG genotype of Ser326Cys was significantly associated with HCC risk in hospital-based (HB) controls (GG versus CC: OR=2.31, 95% CI=1.50-3.56; GG versus CG + CC: OR=2.17, 95% CI=1.44-3.28), as well as in population-based (PB) models (GG vs. CC: OR=2.80, 95% CI=1.16-6.77; GG versus CG + CC: OR=2.39, 95% CI=1.08-5.30).

CONCLUSIONS

According to the results, hOGG1 Ser326Cys polymorphism was associated with increased risk of HCC.

摘要

背景

近期文献中，人8-氧鸟嘌呤DNA糖苷酶1（hOGG1）丝氨酸326位点突变为半胱氨酸（Ser326Cys）多态性与肝癌（HCC）之间的关系并不一致。基于既往研究进行的本次荟萃分析旨在对此问题进行精确评估。

方法

通过计算机检索PubMed、中国生物医学文献数据库（CBM）和荷兰医学文摘数据库（EMBASE）。共有9篇病例对照研究纳入本次荟萃分析，涉及2583例肝癌患者和2271例对照。计算合并比值比（OR）及95%置信区间（CI）以评估Ser326Cys多态性与肝癌易感性的关系。采用Z检验评估合并OR的显著性。根据异质性采用固定效应模型或随机效应模型。

结果

总体而言，在以下遗传模型下，hOGG1 Ser326Cys多态性与肝癌风险增加相关：GG与CC比较：OR = 2.51，95%CI = 1.67 - 3.78；GG与CG + CC比较：OR = 2.27，95%CI = 1.57 - 3.30；GG + CG与CC比较：OR = 1.13，95%CI = 1.03 - 1.24。按种族进行的亚组分析表明，GG和GG + CG基因型的亚洲人患肝癌风险较高（GG与CC比较：OR = 2.17，95%CI = 1.49 - 3.17；GG与CG + CC比较：OR = 1.96，95%CI = 1.41 - 2.73；GG + CG与CC比较：OR = 1.13，95%CI = 1.03 - 1.25）。基于对照来源的亚组分析显示，Ser326Cys的GG基因型在基于医院的（HB）对照中（GG与CC比较：OR = 2.31，95%CI = 1.50 - 3.56；GG与CG + CC比较：OR = 2.17，95%CI = 1.44 - 3.28）以及基于人群的（PB）模型中（GG与CC比较：OR = 2.80，95%CI = 1.16 - 6.77；GG与CG + CC比较：OR = 2.39，95%CI = 1.08 - 5.30）均与肝癌风险显著相关。