Department of Radiology, Beijing Anzhen Hospital,Capital Medical University, Beijing, China.
Int J Cardiovasc Imaging. 2010 Feb;26 Suppl 1:83-92. doi: 10.1007/s10554-009-9569-4.
We wanted to assess the performance of dual-source CT (DSCT) for evaluating the left atrial volume and function and we compared this performance to that of the standard reference technique,cardiac cine MR (CMR). Fifty-one patients who were referred for CT coronary angiography were included in the study. Two were subsequently excluded for having un-analyzable MR images at the onset of left atrial contraction. For the remaining 49 patients, the DSCT data sets and FIESTA (fast imaging employing steady-state acquisition) cines of the vertical long axis covering the left atrium and the short axis covering the left ventricle were obtained on the same day. All the images were analyzed to obtain the maximal left atrial volume (LAVmax), the minimal left atrial volume (LAVmin), the left atrial volume just before left atrium contraction (LAVp), the left atrial reservoir volume (LARV), the left atrial ejection fraction (LAEF), the left atrial passive emptying volume (LAPV), the left atrial active emptying volume(LAAV), the left atrial conduit volume (LACV), the left ventricular end-diastolic volume (LVEDV), the left ventricular end-systolic volume (LVESV) and the left ventricular stroke volume (LVSV) by using 3D semi-segmentation software and Report Card 2.0 software, respectively, for the DSCT and CMR. All the parameters were normalized to the body surface area. Intermodality agreement was tested through linear regression and Bland-Altman analyses.Repeated measurements were performed to determine the interobserver variability. The DSCT measurements resulted in good correlation (r > 0.75) compared with those of CMR. However, DSCT slightly,but insignificantly overestimated the indexed LAVmax, LAVmin, LAVp, LARV, LAPV, LAAV and LACV, as reflected by biases of 1.2, 0.9, 1.1, 0.3, 0.1,0.2 and 0.4 ml/m(2), respectively. The LAEF was minimally, but insignificantly underestimated as reflected by a bias of -0.6% (P = ns). The variability of the DSCT measurements was lower than that of the CMR values. DSCT provides highly reliable and reproducible measurements of the left atrial phasic volume and function in patients who are referred for coronary CT imaging.
我们旨在评估双源 CT（DSCT）在评估左心房容积和功能方面的性能，并将其与标准参考技术——心脏电影磁共振（CMR）进行比较。研究纳入了 51 例因 CT 冠状动脉造影而就诊的患者。其中 2 例因左心房收缩起始时无法分析 MR 图像而被排除在外。对于其余 49 例患者，在同一天获得了覆盖左心房的垂直长轴的 DSCT 数据集和 FIESTA（稳态采集快速成像）电影以及覆盖左心室的短轴电影。所有图像均进行分析以获得最大左心房容积（LAVmax）、最小左心房容积（LAVmin）、左心房收缩前的左心房容积（LAVp）、左心房储备容积（LARV）、左心房射血分数（LAEF）、左心房被动排空容积（LAPV）、左心房主动排空容积（LAAV）、左心房传导容积（LACV）、左心室舒张末期容积（LVEDV）、左心室收缩末期容积（LVESV）和左心室每搏量（LVSV）。使用 3D 半自动分割软件和 Report Card 2.0 软件分别对 DSCT 和 CMR 进行分析。所有参数均按体表面积进行归一化。通过线性回归和 Bland-Altman 分析测试了模态间的一致性。进行了重复测量以确定观察者间的变异性。与 CMR 相比，DSCT 测量结果具有很好的相关性（r>0.75）。然而，DSCT 略微但无统计学意义地高估了左心房指数 LAVmax、LAVmin、LAVp、LARV、LAPV、LAAV 和 LACV，分别反映为偏差 1.2、0.9、1.1、0.3、0.1、0.2 和 0.4ml/m2。LAEF 被低估，偏差为-0.6%（P=ns）。DSCT 测量的变异性低于 CMR 值。DSCT 为因冠状动脉 CT 成像而就诊的患者提供了高度可靠和可重复的左心房相容积和功能测量。
