Division of Molecular Pharmaceutics, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.
J Biomed Nanotechnol. 2009 Aug;5(4):351-63. doi: 10.1166/jbn.2009.1044.
Lipid-based nanoparticle technology has developed from chemical drug carrier into an efficient multifunctional siRNA tumor targeting delivery system. In this review, we start with an overview of the lipid-based nanomedicine history and the two classes of lipidic vectors for DNA or siRNA delivery. Then we discuss the features of lipid-based nanomedicine that lead to effective tumor targeting and the principles behind. We also discuss nanoparticle surface modification, classes of tumor targeting ligands, and other state-of-the-art strategies for enhancing endosome release primarily focused on lipid-based systems. At the end, we show that multifunctional self-assembled lipid-based nanoparticles could also be versatile delivery vehicles for cancer molecular imaging probes.
基于脂质的纳米颗粒技术已从化学药物载体发展成为一种高效的多功能 siRNA 肿瘤靶向递药系统。在本综述中，我们首先概述了基于脂质的纳米医学的历史以及两类用于 DNA 或 siRNA 递药的脂质载体。然后，我们讨论了导致基于脂质的纳米药物有效靶向肿瘤的特征及其背后的原理。我们还讨论了纳米颗粒表面修饰、肿瘤靶向配体的种类以及其他提高内体释放效率的最新策略，主要集中在基于脂质的系统上。最后，我们展示了多功能自组装的基于脂质的纳米颗粒也可以作为癌症分子成像探针的多功能递药载体。
