Department of Bioengineering, Stanford University, W300 James H. Clark Center, 318 Campus Drive, Stanford, California 94305-5440, USA.
Org Lett. 2010 Feb 5;12(3):492-5. doi: 10.1021/ol902660p.
Peptoids, oligo-N-substituted glycines, can fold into well-defined helical secondary structures. The design and synthesis of new peptoid building blocks that are capable of both (a) inducing a helical secondary structure and (b) decorating the helices with chemical functionalities are reported. Peptoid heptamers containing carboxamide, carboxylic acid or thiol functionalities were synthesized, and the resulting peptoids were shown to form stable helices. A thiol-containing peptoid readily formed the homodisulfide, providing a convenient route to prepare peptoid helix homodimers.
肽缩氨酸,寡 N-取代的甘氨酸,可以折叠成明确的螺旋二级结构。本文报道了设计和合成新的肽缩氨酸砌块的方法,这些砌块既能(a)诱导螺旋二级结构,又能(b)用化学官能团修饰螺旋。合成了含有酰胺基、羧酸基或巯基官能团的肽缩氨酸七聚体,结果表明这些肽缩氨酸能够形成稳定的螺旋。含有巯基的肽缩氨酸很容易形成同二硫键,为制备肽缩氨酸螺旋同二聚体提供了一种方便的途径。