Kenya Medical Research Institute (KEMRI)/Wellcome Trust Collaborative Research Programme, Kilifi, Kenya.
Trends Parasitol. 2010 Mar;26(3):125-9. doi: 10.1016/j.pt.2009.12.002. Epub 2010 Jan 6.
The emergence of artemisinin resistance could adversely impact the current strategy for malaria treatment; thus, new drugs are urgently needed. A possible approach to developing new antimalarials is to find new uses for old drugs. Some anticancer agents such as methotrexate and trimetrexate are active against malaria. However, they are commonly perceived to be toxic and thus not suitable for malaria treatment. In this opinion article, we examine how the toxicity of anticancer agents is just a matter of dose or 'only dose makes the poison', as coined in Paracelsus' law. Thus, the opportunity exists to discover new antimalarials using the anticancer pharmacopoeia.
青蒿素耐药性的出现可能会对当前的疟疾治疗策略产生不利影响；因此，急需新的药物。开发新的抗疟药物的一种可能方法是寻找旧药物的新用途。一些抗癌药物，如甲氨蝶呤和三氨蝶呤，对疟疾具有活性。然而，它们通常被认为是有毒的，因此不适合用于疟疾治疗。在这篇观点文章中，我们探讨了抗癌药物的毒性如何只是剂量的问题，或者像帕拉塞尔苏斯定律所指出的那样，“只有剂量才能使毒物变成药物”。因此，利用抗癌药物学发现新的抗疟药物是有可能的。
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