Human & Molecular Genetics Center at Medical College of Wisconsin, USA.
Brief Bioinform. 2010 Jul;11(4):431-9. doi: 10.1093/bib/bbp069. Epub 2010 Jan 7.
Rat models have been used to investigate physiological and pathophysiological mechanisms for decades. With the availability of the rat genome and other online resources, tools to identify rat models that mimic human disease are an important step in translational research. Despite the large number of papers published each year using rat models, integrating this information remains a problem. Resources for the rat genome are continuing to grow rapidly, while resources providing access to rat phenotype data are just emerging. An overview of rat models of disease, tools to characterize strain by phenotype and genotype, and steps being taken to integrate rat physiological data is presented in this article. Integrating functional and physiological data with the rat genome will build a solid research platform to facilitate innovative studies to unravel the mechanisms resulting in disease.
几十年来，老鼠模型一直被用于研究生理和病理生理学机制。随着大鼠基因组和其他在线资源的出现，识别模拟人类疾病的大鼠模型的工具是转化研究的重要一步。尽管每年都有大量使用大鼠模型的论文发表，但整合这些信息仍然是一个问题。大鼠基因组的资源在持续快速增长，而提供大鼠表型数据访问的资源才刚刚出现。本文概述了疾病大鼠模型、用于通过表型和基因型来描述品系的工具，以及整合大鼠生理数据所采取的步骤。将功能和生理数据与大鼠基因组整合将构建一个坚实的研究平台，以促进创新性研究，揭示导致疾病的机制。
