台湾中老年人群的高血压前期：一项为期五年的随访研究。

Prehypertension among middle-aged and elderly people in Taiwan: a five-year follow-up.

机构信息

Division of Geriatric Medicine, Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

出版信息

J Atheroscler Thromb. 2010 Feb 26;17(2):189-94. doi: 10.5551/jat.2832. Epub 2010 Jan 7.

DOI:10.5551/jat.2832

PMID:20057172

Abstract

AIM

To evaluate the prevalence of prehypertension among middle-aged and elderly people in Taiwan and to explore the evolutionary changes of blood pressure in 5-year follow-up period.

METHODS

In 2000, people aged over 40 participating in annual health examinations at local health stations in I-Lan County were invited to join the study. Past medical histories were reviewed, physical examinations and serial laboratory tests were performed for participants. All participants were followed in 2005 by a medical record review, telephone survey or personal visit. Subjects with prehypertension were sorted for further analysis.

RESULTS

Overall, 1053 people (mean age=64.4+/-11.4 years, 44.4% males) were enrolled in the primary cohort. The prevalence of hypertension and prehypertension was 40.4% and 35.8%, respectively. In 2005, 677 subjects (mean age: 68.8+/-10.4 years, 42.5% males) were successfully followed, which revealed a significant increase of systolic blood pressure (3.7+/-16.8 mmHg, p<0.001), but not diastolic blood pressure (0.3+/-11.5 mmHg, p=0.758) in prehypertensive subjects; however, both systolic blood pressure (14.3+/-17.4 mmHg, p<0.001) and diastolic blood pressure (7.7+/-13.3 mmHg, p<0.001) were significantly increased among normotensive subjects. The cumulative incidence of prehypertensive subjects becoming hypertensive was 31.3%, and those who became hypertensive were significantly older (65.3+/-8.6 vs. 62.2+/-12.3 years, p=0.024), having higher pulse pressure in 2000 (49.6+/-10.6 vs. 45.1+/-11.6 mmHg, p=0.001), serum total cholesterol (214.3+/-31.7 vs. 204.0+/-37.2 mg/dL, p=0.020) and low-density lipoprotein-cholesterol (141.7+/-29.2 vs. 132.7+/-34.7 mg/dL, p=0.042).

CONCLUSIONS

The prevalence of prehypertension among older Taiwanese was 35.8% and the 5-year cumulative incidence of hypertension from prehypertension was 31.3%. Older prehypertensive subjects with higher pulse pressure, higher serum total cholesterol and higher low-density lipoprotein-cholesterol were more likely to become hypertensive within 5 years.

摘要

目的

评估台湾中老年人群的高血压前期患病率，并探讨血压在 5 年随访期间的演变变化。

方法

2000 年，邀请在宜兰县当地健康站参加年度健康检查的 40 岁以上人群参加研究。回顾既往病史，对参与者进行体格检查和系列实验室检查。所有参与者在 2005 年通过病历复查、电话调查或个人访视进行随访。对高血压前期患者进行分类进一步分析。

结果

总体而言，共有 1053 人（平均年龄=64.4+/-11.4 岁，44.4%男性）入组初级队列。高血压和高血压前期的患病率分别为 40.4%和 35.8%。2005 年，677 名受试者（平均年龄：68.8+/-10.4 岁，42.5%男性）成功随访，结果显示高血压前期患者的收缩压显著升高（3.7+/-16.8mmHg，p<0.001），但舒张压无显著变化（0.3+/-11.5mmHg，p=0.758）；然而，正常血压患者的收缩压（14.3+/-17.4mmHg，p<0.001）和舒张压（7.7+/-13.3mmHg，p<0.001）均显著升高。高血压前期患者发展为高血压的累积发病率为 31.3%，发展为高血压的患者年龄明显较大（65.3+/-8.6 岁比 62.2+/-12.3 岁，p=0.024），2000 年时脉压更高（49.6+/-10.6mmHg 比 45.1+/-11.6mmHg，p=0.001），血清总胆固醇（214.3+/-31.7mg/dL 比 204.0+/-37.2mg/dL，p=0.020）和低密度脂蛋白胆固醇（141.7+/-29.2mg/dL 比 132.7+/-34.7mg/dL，p=0.042）也更高。