Department of Obstetrics and Gynecology, Turgut Özal University Medical School, Ankara, Turkey.
Gynecol Obstet Invest. 2013;75(3):203-9. doi: 10.1159/000348560. Epub 2013 Mar 15.
BACKGROUND/AIMS: Visfatin is a novel adipokine with insulinomimetic properties that increases in diabetes. However, for gestational diabetes mellitus (GDM) there are conflicting reports. Recent studies have reported a positive association of serum ferritin concentrations with insulin resistance. Thus, we assessed serum levels of visfatin in pregnant women with varying degrees of glucose tolerance and investigated the possible interaction of visfatin with parameters of iron metabolism.
Visfatin levels were measured at 24-28 weeks of gestation in 88 women who were divided into three groups according to their response to a 50-gram glucose challenge test and a 100-gram oral glucose tolerance test: control group (n = 28), impaired glucose tolerance (IGT) group (n = 30) and GDM group (n = 30).
Visfatin levels were significantly higher in the GDM and IGT group than in control (p < 0.001 for GDM vs. control, and p = 0.004 for IGT vs. control). Serum visfatin was significantly associated with serum ferritin, insulin, age, gravidity, and body mass index. In a linear regression model, the covariates explained only 17% of variability of serum visfatin concentration. Body mass index (p < 0.001) contributed independently to visfatin variance.
Serum visfatin concentration is significantly higher in GDM and is correlated with ferritin levels.
背景/目的：内脂素是一种具有胰岛素模拟作用的新型脂肪因子，在糖尿病中会增加。然而，对于妊娠糖尿病（GDM），有相互矛盾的报道。最近的研究报告称，血清铁蛋白浓度与胰岛素抵抗呈正相关。因此，我们评估了不同葡萄糖耐量孕妇的血清内脂素水平，并研究了内脂素与铁代谢参数的可能相互作用。
在 88 名孕妇中，根据其对 50 克葡萄糖挑战试验和 100 克口服葡萄糖耐量试验的反应，在 24-28 周妊娠时测量内脂素水平，将她们分为三组：对照组（n=28）、糖耐量受损（IGT）组（n=30）和 GDM 组（n=30）。
GDM 组和 IGT 组的内脂素水平明显高于对照组（GDM 组与对照组相比，p<0.001；IGT 组与对照组相比，p=0.004）。血清内脂素与血清铁蛋白、胰岛素、年龄、孕次和体重指数显著相关。在线性回归模型中，协变量仅能解释血清内脂素浓度变异性的 17%。体重指数（p<0.001）对内脂素的变异性有独立贡献。
GDM 患者的血清内脂素浓度显著升高，并与铁蛋白水平相关。
