Gottardello L, Dalrì L, Di Mario F, Burra P, Dotto P, Leandro G, Contento F, Torri A, Salvagnini M, Naccarato R
Istituto di Medicina Interna, Università di Padova.
Minerva Med. 1991 Mar;82(3):81-5.
Peptic ulcer has been reported with increased frequency in patients with liver cirrhosis, its prevalence ranging form 5% to 20%. The aim of the present study is twofold: 1) to define the frequency of peptic ulcer in chronic liver disease in a large sample of cirrhotic patients, 2) to investigate the epidemiological and clinical features of a group of subjects affected by both peptic ulcer and liver cirrhosis. Two years of admission have been retrospectively investigated to define the frequency of peptic ulcer in chronic liver disease. In 237 subjects affected by both cirrhosis and peptic ulcer, epidemiological and clinical data were collected. Peptic ulcer was present in 16% of cirrhotic patients. There were no differences between ulcer subjects who drank and those did not. A linear positive correlation between smoking habit and frequency of ulcer disease has been found in the words. A positive history for peptic ulcer was described in a little subgroup of the studied sample, suggesting a low importance of the genetic factor in the pathophysiological pattern of ulcer disease in chronic hepatitis.
据报道，肝硬化患者中消化性溃疡的发病率有所增加，其患病率在5%至20%之间。本研究的目的有两个：1）在大量肝硬化患者样本中确定慢性肝病中消化性溃疡的发病率，2）调查一组同时患有消化性溃疡和肝硬化的患者的流行病学和临床特征。对两年的入院病例进行回顾性调查，以确定慢性肝病中消化性溃疡的发病率。收集了237例同时患有肝硬化和消化性溃疡患者的流行病学和临床数据。16%的肝硬化患者存在消化性溃疡。饮酒的溃疡患者和不饮酒的溃疡患者之间没有差异。研究发现吸烟习惯与溃疡病发病率之间存在线性正相关。在研究样本的一小部分中描述了消化性溃疡的阳性病史，这表明遗传因素在慢性肝炎溃疡病病理生理模式中的重要性较低。
