Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal.
Autoimmun Rev. 2010 Jun;9(8):531-5. doi: 10.1016/j.autrev.2009.12.013. Epub 2010 Jan 7.
Rheumatoid arthritis is the most common inflammatory joint disease. The etiopathogenesis of this condition has been classically explained by a T cell-driven process. However, recent studies have highlighted the possible contribution of neutrophils for the early phases of RA physiopathology. These cells are phagocytic leukocytes that play crucial roles in the acute defense against pathogens while modulating the function of other immune cells and contributing to the perpetuation of an initial inflammatory response. The herein article reviews recent progresses in the understanding of the immunopathology of RA with a special emphasis on the role of neutrophils.
类风湿关节炎是最常见的炎性关节病。这种疾病的病因学经典上被解释为 T 细胞驱动的过程。然而，最近的研究强调了中性粒细胞可能对 RA 病理生理学的早期阶段有贡献。这些细胞是吞噬性白细胞，在对抗病原体的急性防御中发挥着至关重要的作用，同时调节其他免疫细胞的功能，并有助于初始炎症反应的持续。本文综述了对 RA 免疫病理学理解的最新进展，特别强调了中性粒细胞的作用。
