Lipid Research Center, CHUQ-CHUL Pavilion, Québec, Québec, Canada.
Maturitas. 2010 Jun;66(2):158-62. doi: 10.1016/j.maturitas.2009.12.015. Epub 2010 Jan 8.
The proportion of elderly is growing worldwide. This trend is in parallel to an increase in diseases, such as cardiovascular disease (CVD). Plant sterols and stanols (PS) consumption is known to decrease low-density lipoprotein-cholesterol (LDL-C) levels by 5-15%, and thus lower CVD risk. Yet, the effect of PS on LDL-C levels differs between individuals. Furthermore, PS have recently been investigated for the prevention of other age-related diseases. The objective of this review is to examine the benefits of PS on CVD as well as ageing-associated diseases. PS have the ability to significantly lower LDL-C; yet, the large inter-individual variability in the lowering of LDL-C may be due to subject characteristics, food matrix of PS, dose of PS, dietary background, frequency of intake of PS, the additive effect of other foods or drugs, as well as genetic factors. Further, PS may also have other potential beneficial effects including anti-atherogenic, anti-inflammatory, antioxidant and anti-cancer activities. Overall, dietary intervention strategies, such as incorporating PS into a healthy diet, should be recommended and implemented in older adult populations in order to prevent ageing-associated diseases and hence promote healthy ageing.
全球老年人口比例不断增加。这种趋势与心血管疾病 (CVD) 等疾病的增加是并行的。已知植物甾醇和甾烷醇 (PS) 的摄入可使低密度脂蛋白胆固醇 (LDL-C) 水平降低 5-15%，从而降低 CVD 风险。然而，PS 对 LDL-C 水平的影响在个体之间存在差异。此外，PS 最近也被用于预防其他与年龄相关的疾病。本综述的目的是检查 PS 对 CVD 以及与衰老相关疾病的益处。PS 具有显著降低 LDL-C 的能力；然而，LDL-C 降低的个体间差异很大，可能是由于受试者特征、PS 的食物基质、PS 的剂量、饮食背景、PS 的摄入频率、其他食物或药物的相加作用以及遗传因素。此外，PS 还可能具有其他潜在的有益作用，包括抗动脉粥样硬化、抗炎、抗氧化和抗癌作用。总的来说，应该推荐并在老年人群中实施饮食干预策略，例如将 PS 纳入健康饮食，以预防与衰老相关的疾病，从而促进健康衰老。
