Just M, Kahaly G, Higer H P, Rösler H P, Kutzner J, Beyer J, Thelen M
Institut für klinische Strahlenkunde, Johannes Gutenberg Universität Mainz, Federal Republic of Germany.
Radiology. 1991 Apr;179(1):187-90. doi: 10.1148/radiology.179.1.2006276.
Twenty-three patients with Graves ophthalmopathy who underwent radiation therapy were monitored by means of magnetic resonance (MR) imaging. T2 relaxation times of extraocular muscles and orbital fat, areas of extraocular muscles, and degree of exophthalmos were measured by means of MR imaging at the beginning, at the end, and 3 months after completion of radiation therapy. As a result, patients with primarily elevated T2 times of extraocular muscles showed a better therapy response regarding muscle thickening than patients with primarily normal T2 times. Elevated T2 times, which probably represent acute inflammatory changes, were markedly decreased at the end of therapy. Therefore, quantitative MR imaging favors the choice of anti-inflammatory therapy regimens in patients with elevated T2 times of extraocular muscles. However, the clinical response (activity scores) to the low-dose treatment protocol that was used did not correlate well with primarily elevated T2 times. Furthermore, T2 times increased again after cessation of therapy. Whether a higher radiation dose or a different fractionation scheme leads to better results must be clarified by means of further study.
对23例接受放射治疗的格雷夫斯眼病患者进行了磁共振（MR）成像监测。在放射治疗开始时、结束时以及结束后3个月，通过MR成像测量眼外肌和眶脂肪的T2弛豫时间、眼外肌面积和眼球突出度。结果显示，与T2时间主要正常的患者相比，眼外肌T2时间主要升高的患者在肌肉增厚方面的治疗反应更好。可能代表急性炎症变化的升高的T2时间在治疗结束时明显降低。因此，定量MR成像有助于为眼外肌T2时间升高的患者选择抗炎治疗方案。然而，所采用的低剂量治疗方案的临床反应（活动评分）与T2时间主要升高情况的相关性不佳。此外，治疗停止后T2时间再次升高。更高的放射剂量或不同的分割方案是否能带来更好的结果，必须通过进一步研究来阐明。
